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Heterogeneous pathways and timing of factor departure during translation initiation

Author

Listed:
  • Albert Tsai

    (Stanford University School of Medicine
    Stanford University)

  • Alexey Petrov

    (Stanford University School of Medicine)

  • R. Andrew Marshall

    (Stanford University School of Medicine
    McKinsey & Company - Silicon Valley, 3705A Hansen Way)

  • Jonas Korlach

    (Pacific Biosciences, 1380 Willow Rd)

  • Sotaro Uemura

    (Stanford University School of Medicine
    Omics Science Center, RIKEN Yokohama Institute, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama City, Kanagawa 230-0045, Japan)

  • Joseph D. Puglisi

    (Stanford University School of Medicine
    Stanford Magnetic Resonance Laboratory, Stanford University School of Medicine)

Abstract

A single-molecule approach is used to investigate the kinetics of assembly of the translation initiation complex, revealing that there is more than one pathway by which the necessary factors can assemble.

Suggested Citation

  • Albert Tsai & Alexey Petrov & R. Andrew Marshall & Jonas Korlach & Sotaro Uemura & Joseph D. Puglisi, 2012. "Heterogeneous pathways and timing of factor departure during translation initiation," Nature, Nature, vol. 487(7407), pages 390-393, July.
    • Handle: RePEc:nat:nature:v:487:y:2012:i:7407:d:10.1038_nature11172
    DOI: 10.1038/nature11172
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    Cited by:

    1. Ritwika S. Basu & Michael B. Sherman & Matthieu G. Gagnon, 2022. "Compact IF2 allows initiator tRNA accommodation into the P site and gates the ribosome to elongation," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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