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Structure of the immature retroviral capsid at 8 Å resolution by cryo-electron microscopy

Author

Listed:
  • Tanmay A. M. Bharat

    (Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany)

  • Norman E. Davey

    (Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany)

  • Pavel Ulbrich

    (Institute of Chemical Technology, Prague, Technicka 3, 166 28 Prague, Czech Republic)

  • James D. Riches

    (Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany)

  • Alex de Marco

    (Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany)

  • Michaela Rumlova

    (Institute of Organic Chemistry and Biochemistry, Academy of Sciences of Czech Republic, v.v.i., Flemingovo nám. 2, 166 10 Prague, Czech Republic)

  • Carsten Sachse

    (Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany)

  • Tomas Ruml

    (Institute of Chemical Technology, Prague, Technicka 3, 166 28 Prague, Czech Republic)

  • John A. G. Briggs

    (Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany)

Abstract

A hybrid cryo-electron microscopy/tomography approach is used to solve the structure of the immature Mason–Pfizer monkey virus Gag lattice at a resolution of 8 Å, allowing the derivation of a model for the structure of retroviral capsid in the immature Gag shell.

Suggested Citation

  • Tanmay A. M. Bharat & Norman E. Davey & Pavel Ulbrich & James D. Riches & Alex de Marco & Michaela Rumlova & Carsten Sachse & Tomas Ruml & John A. G. Briggs, 2012. "Structure of the immature retroviral capsid at 8 Å resolution by cryo-electron microscopy," Nature, Nature, vol. 487(7407), pages 385-389, July.
    • Handle: RePEc:nat:nature:v:487:y:2012:i:7407:d:10.1038_nature11169
    DOI: 10.1038/nature11169
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