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Immune self-reactivity triggered by drug-modified HLA-peptide repertoire

Author

Listed:
  • Patricia T. Illing

    (University of Melbourne, Parkville, Victoria 3010, Australia
    University of Melbourne, Parkville, Victoria 3010, Australia)

  • Julian P. Vivian

    (School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia)

  • Nadine L. Dudek

    (University of Melbourne, Parkville, Victoria 3010, Australia)

  • Lyudmila Kostenko

    (University of Melbourne, Parkville, Victoria 3010, Australia)

  • Zhenjun Chen

    (University of Melbourne, Parkville, Victoria 3010, Australia)

  • Mandvi Bharadwaj

    (University of Melbourne, Parkville, Victoria 3010, Australia)

  • John J. Miles

    (Queensland Institute of Medical Research and Australian Centre for Vaccine Development
    Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK)

  • Lars Kjer-Nielsen

    (University of Melbourne, Parkville, Victoria 3010, Australia)

  • Stephanie Gras

    (School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia)

  • Nicholas A. Williamson

    (University of Melbourne, Parkville, Victoria 3010, Australia)

  • Scott R. Burrows

    (Queensland Institute of Medical Research and Australian Centre for Vaccine Development)

  • Anthony W. Purcell

    (University of Melbourne, Parkville, Victoria 3010, Australia)

  • Jamie Rossjohn

    (School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
    Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK)

  • James McCluskey

    (University of Melbourne, Parkville, Victoria 3010, Australia
    Victorian Transplantation and Immunogenetics Service, Australian Red Cross Blood Service, 100–154 Batman Street, West Melbourne, Victoria 3003, Australia)

Abstract

The paper describes the mechanism by which small-molecule drugs such as abacavir affect antigen presentation and consequently T-cell response in immunologically based drug reactions such as abacavir hypersensitivity syndrome (AHS) and carbamazepine-induced Stevens–Johnson syndrome (SJS).

Suggested Citation

  • Patricia T. Illing & Julian P. Vivian & Nadine L. Dudek & Lyudmila Kostenko & Zhenjun Chen & Mandvi Bharadwaj & John J. Miles & Lars Kjer-Nielsen & Stephanie Gras & Nicholas A. Williamson & Scott R. B, 2012. "Immune self-reactivity triggered by drug-modified HLA-peptide repertoire," Nature, Nature, vol. 486(7404), pages 554-558, June.
    • Handle: RePEc:nat:nature:v:486:y:2012:i:7404:d:10.1038_nature11147
    DOI: 10.1038/nature11147
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