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PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

Author

Listed:
  • Daniela Cipolletta

    (Harvard Medical School)

  • Markus Feuerer

    (Harvard Medical School
    Present addresses: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany (M.F.); The University of Tokyo, Tokyo 113-8655, Japan (N.K.).)

  • Amy Li

    (Harvard Medical School)

  • Nozomu Kamei

    (Harvard Medical School
    Present addresses: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany (M.F.); The University of Tokyo, Tokyo 113-8655, Japan (N.K.).)

  • Jongsoon Lee

    (Harvard Medical School)

  • Steven E. Shoelson

    (Harvard Medical School)

  • Christophe Benoist

    (Harvard Medical School)

  • Diane Mathis

    (Harvard Medical School)

Abstract

T regulatory (Treg) cells in visceral adipose tissue express high levels of the nuclear receptor peroxisome proliferator-activated receptor (PPAR)-γ, and fat-specific adaptation of Treg cells is dependent on PPAR-γ.

Suggested Citation

  • Daniela Cipolletta & Markus Feuerer & Amy Li & Nozomu Kamei & Jongsoon Lee & Steven E. Shoelson & Christophe Benoist & Diane Mathis, 2012. "PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells," Nature, Nature, vol. 486(7404), pages 549-553, June.
    • Handle: RePEc:nat:nature:v:486:y:2012:i:7404:d:10.1038_nature11132
    DOI: 10.1038/nature11132
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