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Sequence analysis of mutations and translocations across breast cancer subtypes

Author

Listed:
  • Shantanu Banerji

    (The Broad Institute of MIT and Harvard
    Dana-Farber Cancer Institute
    Harvard Medical School
    Present addresses: Department of Medical Oncology, CancerCare Manitoba, Winnipeg, Manitoba R3E 0V9, Canada (S.B.); Global Biotech Consulting Group, Mexico City 01900, Mexico (G.J.-S.).)

  • Kristian Cibulskis

    (The Broad Institute of MIT and Harvard)

  • Claudia Rangel-Escareno

    (Instituto Nacional de Medicina Genómica)

  • Kristin K. Brown

    (Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215)

  • Scott L. Carter

    (The Broad Institute of MIT and Harvard)

  • Abbie M. Frederick

    (The Broad Institute of MIT and Harvard)

  • Michael S. Lawrence

    (The Broad Institute of MIT and Harvard)

  • Andrey Y. Sivachenko

    (The Broad Institute of MIT and Harvard)

  • Carrie Sougnez

    (The Broad Institute of MIT and Harvard)

  • Lihua Zou

    (The Broad Institute of MIT and Harvard)

  • Maria L. Cortes

    (The Broad Institute of MIT and Harvard)

  • Juan C. Fernandez-Lopez

    (Instituto Nacional de Medicina Genómica)

  • Shouyong Peng

    (Dana-Farber Cancer Institute)

  • Kristin G. Ardlie

    (The Broad Institute of MIT and Harvard)

  • Daniel Auclair

    (The Broad Institute of MIT and Harvard)

  • Veronica Bautista-Piña

    (Instituto de Enfermedades de la Mama FUCAM)

  • Fujiko Duke

    (The Broad Institute of MIT and Harvard)

  • Joshua Francis

    (The Broad Institute of MIT and Harvard)

  • Joonil Jung

    (The Broad Institute of MIT and Harvard)

  • Antonio Maffuz-Aziz

    (Instituto de Enfermedades de la Mama FUCAM)

  • Robert C. Onofrio

    (The Broad Institute of MIT and Harvard)

  • Melissa Parkin

    (The Broad Institute of MIT and Harvard)

  • Nam H. Pho

    (The Broad Institute of MIT and Harvard)

  • Valeria Quintanar-Jurado

    (Instituto Nacional de Medicina Genómica)

  • Alex H. Ramos

    (The Broad Institute of MIT and Harvard)

  • Rosa Rebollar-Vega

    (Instituto Nacional de Medicina Genómica)

  • Sergio Rodriguez-Cuevas

    (Instituto de Enfermedades de la Mama FUCAM)

  • Sandra L. Romero-Cordoba

    (Instituto Nacional de Medicina Genómica)

  • Steven E. Schumacher

    (The Broad Institute of MIT and Harvard
    Dana-Farber Cancer Institute)

  • Nicolas Stransky

    (The Broad Institute of MIT and Harvard)

  • Kristin M. Thompson

    (The Broad Institute of MIT and Harvard)

  • Laura Uribe-Figueroa

    (Instituto Nacional de Medicina Genómica)

  • Jose Baselga

    (Harvard Medical School
    Massachusetts General Hospital)

  • Rameen Beroukhim

    (The Broad Institute of MIT and Harvard
    Dana-Farber Cancer Institute
    Harvard Medical School
    Dana-Farber Cancer Institute)

  • Kornelia Polyak

    (Dana-Farber Cancer Institute
    Harvard Medical School
    Brigham and Women’s Hospital)

  • Dennis C. Sgroi

    (Harvard Medical School
    Depertment of Pathology, Massachusetts General Hospital)

  • Andrea L. Richardson

    (Dana-Farber Cancer Institute
    Harvard Medical School
    Brigham and Women's Hospital)

  • Gerardo Jimenez-Sanchez

    (Instituto Nacional de Medicina Genómica
    Present addresses: Department of Medical Oncology, CancerCare Manitoba, Winnipeg, Manitoba R3E 0V9, Canada (S.B.); Global Biotech Consulting Group, Mexico City 01900, Mexico (G.J.-S.).)

  • Eric S. Lander

    (The Broad Institute of MIT and Harvard
    Harvard Medical School
    Massachusetts Institute of Technology)

  • Stacey B. Gabriel

    (The Broad Institute of MIT and Harvard)

  • Levi A. Garraway

    (The Broad Institute of MIT and Harvard
    Dana-Farber Cancer Institute
    Harvard Medical School)

  • Todd R. Golub

    (The Broad Institute of MIT and Harvard
    Harvard Medical School
    Dana-Farber Cancer Institute
    Howard Hughes Medical Institute)

  • Jorge Melendez-Zajgla

    (Instituto Nacional de Medicina Genómica)

  • Alex Toker

    (Harvard Medical School
    Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215)

  • Gad Getz

    (The Broad Institute of MIT and Harvard)

  • Alfredo Hidalgo-Miranda

    (Instituto Nacional de Medicina Genómica)

  • Matthew Meyerson

    (The Broad Institute of MIT and Harvard
    Dana-Farber Cancer Institute
    Harvard Medical School
    Dana-Farber Cancer Institute)

Abstract

This paper reports one of the largest breast cancer whole-exome and whole-genome sequencing efforts so far, identifying previously unknown recurrent mutations in CBFB, deletions of RUNX1 and recurrent MAGI1–AKT3 fusion; the fusion suggests that the use of ATP-competitive AKT inhibitors should be evaluated in clinical trials.

Suggested Citation

  • Shantanu Banerji & Kristian Cibulskis & Claudia Rangel-Escareno & Kristin K. Brown & Scott L. Carter & Abbie M. Frederick & Michael S. Lawrence & Andrey Y. Sivachenko & Carrie Sougnez & Lihua Zou & Ma, 2012. "Sequence analysis of mutations and translocations across breast cancer subtypes," Nature, Nature, vol. 486(7403), pages 405-409, June.
    • Handle: RePEc:nat:nature:v:486:y:2012:i:7403:d:10.1038_nature11154
    DOI: 10.1038/nature11154
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    Cited by:

    1. Qihuang Zhang & Grace Y. Yi, 2023. "Zero‐inflated Poisson models with measurement error in the response," Biometrics, The International Biometric Society, vol. 79(2), pages 1089-1102, June.

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