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PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos

Author

Listed:
  • Toshinobu Nakamura

    (Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
    Present address: Nagahama Institute of Bio-Science and Technology, Shiga 526-0829, Japan.)

  • Yu-Jung Liu

    (Graduate School of Frontier Biosciences, Osaka University, Osaka 565-0871, Japan)

  • Hiroyuki Nakashima

    (Graduate School of Frontier Biosciences, Osaka University, Osaka 565-0871, Japan)

  • Hiroki Umehara

    (Graduate School of Frontier Biosciences, Osaka University, Osaka 565-0871, Japan)

  • Kimiko Inoue

    (RIKEN BioResouce Center, Tsukuba, Ibaraki 305-0074, Japan)

  • Shogo Matoba

    (RIKEN BioResouce Center, Tsukuba, Ibaraki 305-0074, Japan)

  • Makoto Tachibana

    (Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan)

  • Atsuo Ogura

    (RIKEN BioResouce Center, Tsukuba, Ibaraki 305-0074, Japan)

  • Yoichi Shinkai

    (Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan)

  • Toru Nakano

    (Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
    Graduate School of Frontier Biosciences, Osaka University, Osaka 565-0871, Japan)

Abstract

The binding of PGC7 to maternal chromatin, which is important for methylation maintenance during embryogenesis, is shown to be dependent on a particular histone modification, H3K9me2.

Suggested Citation

  • Toshinobu Nakamura & Yu-Jung Liu & Hiroyuki Nakashima & Hiroki Umehara & Kimiko Inoue & Shogo Matoba & Makoto Tachibana & Atsuo Ogura & Yoichi Shinkai & Toru Nakano, 2012. "PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos," Nature, Nature, vol. 486(7403), pages 415-419, June.
    • Handle: RePEc:nat:nature:v:486:y:2012:i:7403:d:10.1038_nature11093
    DOI: 10.1038/nature11093
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    Cited by:

    1. Shiran Bar & Dan Vershkov & Gal Keshet & Elyad Lezmi & Naama Meller & Atilgan Yilmaz & Ofra Yanuka & Malka Nissim-Rafinia & Eran Meshorer & Talia Eldar-Geva & Nissim Benvenisty, 2021. "Identifying regulators of parental imprinting by CRISPR/Cas9 screening in haploid human embryonic stem cells," Nature Communications, Nature, vol. 12(1), pages 1-12, December.

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