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Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors

Author

Listed:
  • Nicola J. Allen

    (Stanford University School of Medicine, 299 Campus Drive, Fairchild Science Building D231, Stanford, California 94305-5125, USA
    Present address: Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.)

  • Mariko L. Bennett

    (Stanford University School of Medicine, 299 Campus Drive, Fairchild Science Building D231, Stanford, California 94305-5125, USA)

  • Lynette C. Foo

    (Stanford University School of Medicine, 299 Campus Drive, Fairchild Science Building D231, Stanford, California 94305-5125, USA)

  • Gordon X. Wang

    (Stanford University School of Medicine, 279 Campus Drive, Beckman Center B100, Stanford, California 94305-5125, USA)

  • Chandrani Chakraborty

    (Stanford University School of Medicine, 299 Campus Drive, Fairchild Science Building D231, Stanford, California 94305-5125, USA)

  • Stephen J. Smith

    (Stanford University School of Medicine, 279 Campus Drive, Beckman Center B100, Stanford, California 94305-5125, USA)

  • Ben A. Barres

    (Stanford University School of Medicine, 299 Campus Drive, Fairchild Science Building D231, Stanford, California 94305-5125, USA)

Abstract

Glypican 4 and glypican 6 are identified as astrocyte-secreted signals that induce the formation of functional, rather than structural, synapses through the recruitment to the neuron surface of the GluA1 subunits of the AMPA glutamate receptor.

Suggested Citation

  • Nicola J. Allen & Mariko L. Bennett & Lynette C. Foo & Gordon X. Wang & Chandrani Chakraborty & Stephen J. Smith & Ben A. Barres, 2012. "Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors," Nature, Nature, vol. 486(7403), pages 410-414, June.
    • Handle: RePEc:nat:nature:v:486:y:2012:i:7403:d:10.1038_nature11059
    DOI: 10.1038/nature11059
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    Cited by:

    1. Shijie Jin & Xuan Chen & Yang Tian & Rachel Jarvis & Vanessa Promes & Yongjie Yang, 2023. "Astroglial exosome HepaCAM signaling and ApoE antagonization coordinates early postnatal cortical pyramidal neuronal axon growth and dendritic spine formation," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Jochen Meyer & Kwanha Yu & Estefania Luna-Figueroa & Benjamin Deneen & Jeffrey Noebels, 2024. "Glioblastoma disrupts cortical network activity at multiple spatial and temporal scales," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Francesco Paolo Ulloa Severino & Oluwadamilola O. Lawal & Kristina Sakers & Shiyi Wang & Namsoo Kim & Alexander David Friedman & Sarah Anne Johnson & Chaichontat Sriworarat & Ryan H. Hughes & Scott H., 2023. "Training-induced circuit-specific excitatory synaptogenesis in mice is required for effort control," Nature Communications, Nature, vol. 14(1), pages 1-22, December.

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