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The clonal and mutational evolution spectrum of primary triple-negative breast cancers

Author

Listed:
  • Sohrab P. Shah

    (University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Andrew Roth

    (University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Rodrigo Goya

    (Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Arusha Oloumi

    (University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Gavin Ha

    (University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Yongjun Zhao

    (Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Gulisa Turashvili

    (University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Jiarui Ding

    (University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Kane Tse

    (Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Gholamreza Haffari

    (University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Ali Bashashati

    (University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Leah M. Prentice

    (University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Jaswinder Khattra

    (University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Angela Burleigh

    (University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Damian Yap

    (University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Virginie Bernard

    (Centre for Molecular Medicine and Therapeutics, 950 West 28th Avenue, Vancouver, British Columbia V5Z 4H4, Canada)

  • Andrew McPherson

    (University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Karey Shumansky

    (University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Anamaria Crisan

    (University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Ryan Giuliany

    (University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Alireza Heravi-Moussavi

    (University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Jamie Rosner

    (University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Daniel Lai

    (University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Inanc Birol

    (Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Richard Varhol

    (Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Angela Tam

    (Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Noreen Dhalla

    (Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Thomas Zeng

    (Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Kevin Ma

    (Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Simon K. Chan

    (Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Malachi Griffith

    (Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Annie Moradian

    (Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • S.-W. Grace Cheng

    (Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Gregg B. Morin

    (Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
    University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada)

  • Peter Watson

    (University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    British Columbia Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada)

  • Karen Gelmon

    (British Columbia Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada)

  • Stephen Chia

    (British Columbia Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada)

  • Suet-Feung Chin

    (Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK)

  • Christina Curtis

    (Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
    Keck School of Medicine, University of Southern California)

  • Oscar M. Rueda

    (Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK)

  • Paul D. Pharoah

    (Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK)

  • Sambasivarao Damaraju

    (University of Alberta, 11560 University Avenue, Cross Cancer Institute, Edmonton, Alberta T6G 1Z2, Canada)

  • John Mackey

    (University of Alberta, 11560 University Avenue, Cross Cancer Institute, Edmonton, Alberta T6G 1Z2, Canada)

  • Kelly Hoon

    (Life Technologies, 101 Lincoln Centre Dr.)

  • Timothy Harkins

    (Life Technologies, 101 Lincoln Centre Dr.)

  • Vasisht Tadigotla

    (Life Technologies, 101 Lincoln Centre Dr.)

  • Mahvash Sigaroudinia

    (University of California)

  • Philippe Gascard

    (University of California)

  • Thea Tlsty

    (University of California)

  • Joseph F. Costello

    (Brain Tumor Research Center, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco)

  • Irmtraud M. Meyer

    (University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
    Centre for High-Throughput Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada)

  • Connie J. Eaves

    (Terry Fox Laboratory, BC Cancer Agency, 675 W 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada)

  • Wyeth W. Wasserman

    (Centre for Molecular Medicine and Therapeutics, 950 West 28th Avenue, Vancouver, British Columbia V5Z 4H4, Canada
    University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada)

  • Steven Jones

    (Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
    University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A1S6, Canada)

  • David Huntsman

    (University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada
    Centre for Translational and Applied Genomics, BC Cancer Agency, 600 West 10th Ave, Vancouver, British Columbia V5Z 4E6, Canada)

  • Martin Hirst

    (Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
    Centre for High-Throughput Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
    University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada)

  • Carlos Caldas

    (Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
    Cambridge Breast Unit, Addenbrookes Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK
    Cambridge Experimental Cancer Medicine Centre (ECMC), Cambridge CB2 0RE, UK)

  • Marco A. Marra

    (Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
    University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada)

  • Samuel Aparicio

    (University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada)

Abstract

Primary triple-negative breast cancers are shown to vary widely and continuously in the degree of clonal evolution and mutational content at the time of diagnosis, with implications for future studies of the disease.

Suggested Citation

  • Sohrab P. Shah & Andrew Roth & Rodrigo Goya & Arusha Oloumi & Gavin Ha & Yongjun Zhao & Gulisa Turashvili & Jiarui Ding & Kane Tse & Gholamreza Haffari & Ali Bashashati & Leah M. Prentice & Jaswinder , 2012. "The clonal and mutational evolution spectrum of primary triple-negative breast cancers," Nature, Nature, vol. 486(7403), pages 395-399, June.
    • Handle: RePEc:nat:nature:v:486:y:2012:i:7403:d:10.1038_nature10933
    DOI: 10.1038/nature10933
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    Citations

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    Cited by:

    1. Zhe Jiang & YoungJun Ju & Amjad Ali & Philip E. D. Chung & Patryk Skowron & Dong-Yu Wang & Mariusz Shrestha & Huiqin Li & Jeff C. Liu & Ioulia Vorobieva & Ronak Ghanbari-Azarnier & Ethel Mwewa & Maria, 2023. "Distinct shared and compartment-enriched oncogenic networks drive primary versus metastatic breast cancer," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    2. Karama Asleh & Gian Luca Negri & Sandra E. Spencer Miko & Shane Colborne & Christopher S. Hughes & Xiu Q. Wang & Dongxia Gao & C. Blake Gilks & Stephen K. L. Chia & Torsten O. Nielsen & Gregg B. Morin, 2022. "Proteomic analysis of archival breast cancer clinical specimens identifies biological subtypes with distinct survival outcomes," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    3. Anna-Lisa Doebley & Minjeong Ko & Hanna Liao & A. Eden Cruikshank & Katheryn Santos & Caroline Kikawa & Joseph B. Hiatt & Robert D. Patton & Navonil De Sarkar & Katharine A. Collier & Anna C. H. Hoge , 2022. "A framework for clinical cancer subtyping from nucleosome profiling of cell-free DNA," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    4. Jiande Wu & Tarun Karthik Kumar Mamidi & Lu Zhang & Chindo Hicks, 2019. "Integrating Germline and Somatic Mutation Information for the Discovery of Biomarkers in Triple-Negative Breast Cancer," IJERPH, MDPI, vol. 16(6), pages 1-16, March.
    5. Brian D. Lehmann & Antonio Colaprico & Tiago C. Silva & Jianjiao Chen & Hanbing An & Yuguang Ban & Hanchen Huang & Lily Wang & Jamaal L. James & Justin M. Balko & Paula I. Gonzalez-Ericsson & Melinda , 2021. "Multi-omics analysis identifies therapeutic vulnerabilities in triple-negative breast cancer subtypes," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    6. Naser Ansari-Pour & Yonglan Zheng & Toshio F. Yoshimatsu & Ayodele Sanni & Mustapha Ajani & Jean-Baptiste Reynier & Avraam Tapinos & Jason J. Pitt & Stefan Dentro & Anna Woodard & Padma Sheila Rajagop, 2021. "Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    7. Peter Eirew & Ciara O’Flanagan & Jerome Ting & Sohrab Salehi & Jazmine Brimhall & Beixi Wang & Justina Biele & Teresa Algara & So Ra Lee & Corey Hoang & Damian Yap & Steven McKinney & Cherie Bates & E, 2022. "Accurate determination of CRISPR-mediated gene fitness in transplantable tumours," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    8. David Otohinoyi & Aditi Kuchi & Jiande Wu & Chindo Hicks, 2022. "Integrating Genomic Information with Tumor-Immune Microenvironment in Triple-Negative Breast Cancer," IJERPH, MDPI, vol. 19(21), pages 1-20, October.
    9. S. Mouron & M. J. Bueno & A. Lluch & L. Manso & I. Calvo & J. Cortes & J. A. Garcia-Saenz & M. Gil-Gil & N. Martinez-Janez & J. V. Apala & E. Caleiras & Pilar Ximénez-Embún & J. Muñoz & L. Gonzalez-Co, 2022. "Phosphoproteomic analysis of neoadjuvant breast cancer suggests that increased sensitivity to paclitaxel is driven by CDK4 and filamin A," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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