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The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

Author

Listed:
  • Pedro A. Pérez-Mancera

    (Li Ka Shing Centre, Cambridge Research Institute, Cancer Research UK, Robinson Way, Cambridge CB2 0RE, UK)

  • Alistair G. Rust

    (Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK)

  • Louise van der Weyden

    (Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK)

  • Glen Kristiansen

    (Institute of Pathology, University Hospital of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany)

  • Allen Li

    (The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions)

  • Aaron L. Sarver

    (Biostatistics and Bioinformatics Core, Masonic Cancer Center, University of Minnesota, 425 Delaware St SE MMC 806, Minneapolis, Minnesota 55455, USA)

  • Kevin A. T. Silverstein

    (Biostatistics and Bioinformatics Core, Masonic Cancer Center, University of Minnesota, 425 Delaware St SE MMC 806, Minneapolis, Minnesota 55455, USA)

  • Robert Grützmann

    (University Hospital Dresden, Fetscherstr. 74, 01307 Dresden, Germany)

  • Daniela Aust

    (Institute of Pathology, University Hospital Dresden, Fetscherstr. 74, 01307 Dresden, Germany)

  • Petra Rümmele

    (Institute of Pathology, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany)

  • Thomas Knösel

    (Institute of Pathology, University Hospital of Jena, Bachstraße 18, 07743 Jena, Germany
    Institute of Pathology, Ludwig-Maximilians-University (LMU), Thalkirchnerstr. 36, 80337 Munich, Germany)

  • Colin Herd

    (Vertebrate Development and Genetics, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK)

  • Derek L. Stemple

    (Vertebrate Development and Genetics, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK)

  • Ross Kettleborough

    (Vertebrate Development and Genetics, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK)

  • Jacqueline A. Brosnan

    (The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions)

  • Ang Li

    (The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions)

  • Richard Morgan

    (The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions)

  • Spencer Knight

    (The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions)

  • Jun Yu

    (The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions)

  • Shane Stegeman

    (Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan, Queensland 4111, Australia)

  • Lara S. Collier

    (School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705, USA)

  • Jelle J. ten Hoeve

    (Delft Bioinformatics Lab, Faculty of EEMCS, Delft University of Technology, 2628 CD Delft, The Netherlands
    Bioinformatics and Statistics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands)

  • Jeroen de Ridder

    (Delft Bioinformatics Lab, Faculty of EEMCS, Delft University of Technology, 2628 CD Delft, The Netherlands)

  • Alison P. Klein

    (The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions)

  • Michael Goggins

    (The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions)

  • Ralph H. Hruban

    (The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions)

  • David K. Chang

    (The Kinghorn Cancer Centre, Cancer Research Program, Garvan Institute of Medical Research, 372 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia
    Bankstown Hospital, Eldridge Road, Bankstown, Sydney, New South Wales 2200, Australia
    South Western Sydney Clinical School, Faculty of Medicine, University of NSW, Liverpool, New South Wales 2170, Australia)

  • Andrew V. Biankin

    (The Kinghorn Cancer Centre, Cancer Research Program, Garvan Institute of Medical Research, 372 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia
    Bankstown Hospital, Eldridge Road, Bankstown, Sydney, New South Wales 2200, Australia
    South Western Sydney Clinical School, Faculty of Medicine, University of NSW, Liverpool, New South Wales 2170, Australia)

  • Sean M. Grimmond

    (Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia)

  • Lodewyk F. A. Wessels

    (Delft Bioinformatics Lab, Faculty of EEMCS, Delft University of Technology, 2628 CD Delft, The Netherlands
    Bioinformatics and Statistics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands)

  • Stephen A. Wood

    (Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan, Queensland 4111, Australia)

  • Christine A. Iacobuzio-Donahue

    (The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions)

  • Christian Pilarsky

    (University Hospital Dresden, Fetscherstr. 74, 01307 Dresden, Germany)

  • David A. Largaespada

    (Masonic Cancer Center, University of Minnesota)

  • David J. Adams

    (Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK)

  • David A. Tuveson

    (Li Ka Shing Centre, Cambridge Research Institute, Cancer Research UK, Robinson Way, Cambridge CB2 0RE, UK)

Abstract

An in vivo transposon screen in a pancreatic cancer model identifies frequent inactivation of Usp9x; deletion of Usp9x cooperates with KrasG12D to accelerate rapidly pancreatic tumorigenesis in mice, validating their genetic interaction.

Suggested Citation

  • Pedro A. Pérez-Mancera & Alistair G. Rust & Louise van der Weyden & Glen Kristiansen & Allen Li & Aaron L. Sarver & Kevin A. T. Silverstein & Robert Grützmann & Daniela Aust & Petra Rümmele & Thomas K, 2012. "The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma," Nature, Nature, vol. 486(7402), pages 266-270, June.
    • Handle: RePEc:nat:nature:v:486:y:2012:i:7402:d:10.1038_nature11114
    DOI: 10.1038/nature11114
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    Citations

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    Cited by:

    1. Mengru Ma & Lian Yi & Yifei Pei & Qimin Zhang & Chao Tong & Manyu Zhao & Yuanhong Chen & Jinghan Zhu & Wanguang Zhang & Fan Yao & Pengyuan Yang & Peijing Zhang, 2024. "USP26 as a hepatitis B virus-induced deubiquitinase primes hepatocellular carcinogenesis by epigenetic remodeling," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Kinzy Tyler G. & Starr Timothy K. & Tseng George C. & Ho Yen-Yi, 2019. "Meta-analytic framework for modeling genetic coexpression dynamics," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 18(1), pages 1-13, February.

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