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Atomic model of the type III secretion system needle

Author

Listed:
  • Antoine Loquet

    (Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany)

  • Nikolaos G. Sgourakis

    (University of Washington)

  • Rashmi Gupta

    (Max Planck Institute for Infection Biology, 10117 Berlin, Germany)

  • Karin Giller

    (Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany)

  • Dietmar Riedel

    (Laboratory for Electron Microscopy, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany)

  • Christian Goosmann

    (Core Facility Microscopy, Max Planck Institute for Infection Biology, 10117 Berlin, Germany)

  • Christian Griesinger

    (Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany)

  • Michael Kolbe

    (Max Planck Institute for Infection Biology, 10117 Berlin, Germany)

  • David Baker

    (University of Washington)

  • Stefan Becker

    (Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany)

  • Adam Lange

    (Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany)

Abstract

The structure of the needle of the type III secretion system of Salmonella typhimurium, used to inject virulence proteins into host cells during infection, has been resolved by a combination of in vitro needle production, solid-state nuclear magnetic resonance, electron microscopy and Rosetta modelling at atomic resolution.

Suggested Citation

  • Antoine Loquet & Nikolaos G. Sgourakis & Rashmi Gupta & Karin Giller & Dietmar Riedel & Christian Goosmann & Christian Griesinger & Michael Kolbe & David Baker & Stefan Becker & Adam Lange, 2012. "Atomic model of the type III secretion system needle," Nature, Nature, vol. 486(7402), pages 276-279, June.
    • Handle: RePEc:nat:nature:v:486:y:2012:i:7402:d:10.1038_nature11079
    DOI: 10.1038/nature11079
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    Cited by:

    1. Yunpeng Liu & Huihui Zhang & Jing Wang & Wenting Gao & Xiting Sun & Qin Xiong & Xia Shu & Youzhi Miao & Qirong Shen & Weibing Xun & Ruifu Zhang, 2024. "Nonpathogenic Pseudomonas syringae derivatives and its metabolites trigger the plant “cry for help” response to assemble disease suppressing and growth promoting rhizomicrobiome," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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