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Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2

Author

Listed:
  • Michael J. Schmeisser

    (Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany)

  • Elodie Ey

    (Human Genetics and Cognitive Functions, Institut Pasteur, 75724 Paris CEDEX 15, France
    CNRS, URA 2182 ‘Genes, Synapses and Cognition’, Institut Pasteur, 75724 Paris CEDEX 15, France
    University Paris Diderot, Sorbonne Paris Cité, Human Genetics and Cognitive Functions, 75013 Paris, France)

  • Stephanie Wegener

    (Neuroscience Research Center, Cluster of Excellence NeuroCure, Charité, 10117 Berlin, Germany)

  • Juergen Bockmann

    (Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany)

  • A. Vanessa Stempel

    (Neuroscience Research Center, Cluster of Excellence NeuroCure, Charité, 10117 Berlin, Germany)

  • Angelika Kuebler

    (Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany)

  • Anna-Lena Janssen

    (Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany)

  • Patrick T. Udvardi

    (Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany)

  • Ehab Shiban

    (Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany
    Present address: Klinikum rechts der Isar, Technische Universität München, Neurosurgery Department, Ismaninger Str. 22, 81675 Munich, Germany.)

  • Christina Spilker

    (PG Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany)

  • Detlef Balschun

    (Laboratory of Biological Psychology, Catholic University of Leuven, 3000 Leuven, Belgium)

  • Boris V. Skryabin

    (Institute of Experimental Pathology (ZMBE), University of Muenster, 48149 Muenster, Germany
    Interdisciplinary Center for Clinical Research (IZKF), University of Muenster, 48149 Muenster, Germany)

  • Susanne tom Dieck

    (Max Planck Institute for Brain Research, 60528 Frankfurt, Germany)

  • Karl-Heinz Smalla

    (Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany)

  • Dirk Montag

    (Neurogenetics Special Laboratory, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany)

  • Claire S. Leblond

    (Human Genetics and Cognitive Functions, Institut Pasteur, 75724 Paris CEDEX 15, France
    CNRS, URA 2182 ‘Genes, Synapses and Cognition’, Institut Pasteur, 75724 Paris CEDEX 15, France
    University Paris Diderot, Sorbonne Paris Cité, Human Genetics and Cognitive Functions, 75013 Paris, France)

  • Philippe Faure

    (University Paris 06, CNRS, UMR 7102, 75005 Paris, France)

  • Nicolas Torquet

    (Human Genetics and Cognitive Functions, Institut Pasteur, 75724 Paris CEDEX 15, France
    CNRS, URA 2182 ‘Genes, Synapses and Cognition’, Institut Pasteur, 75724 Paris CEDEX 15, France
    University Paris Diderot, Sorbonne Paris Cité, Human Genetics and Cognitive Functions, 75013 Paris, France)

  • Anne-Marie Le Sourd

    (Human Genetics and Cognitive Functions, Institut Pasteur, 75724 Paris CEDEX 15, France
    CNRS, URA 2182 ‘Genes, Synapses and Cognition’, Institut Pasteur, 75724 Paris CEDEX 15, France
    University Paris Diderot, Sorbonne Paris Cité, Human Genetics and Cognitive Functions, 75013 Paris, France)

  • Roberto Toro

    (Human Genetics and Cognitive Functions, Institut Pasteur, 75724 Paris CEDEX 15, France
    CNRS, URA 2182 ‘Genes, Synapses and Cognition’, Institut Pasteur, 75724 Paris CEDEX 15, France
    University Paris Diderot, Sorbonne Paris Cité, Human Genetics and Cognitive Functions, 75013 Paris, France)

  • Andreas M. Grabrucker

    (Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany)

  • Sarah A. Shoichet

    (Neuroscience Research Center, Cluster of Excellence NeuroCure, Charité, 10117 Berlin, Germany)

  • Dietmar Schmitz

    (Neuroscience Research Center, Cluster of Excellence NeuroCure, Charité, 10117 Berlin, Germany)

  • Michael R. Kreutz

    (PG Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany)

  • Thomas Bourgeron

    (Human Genetics and Cognitive Functions, Institut Pasteur, 75724 Paris CEDEX 15, France
    CNRS, URA 2182 ‘Genes, Synapses and Cognition’, Institut Pasteur, 75724 Paris CEDEX 15, France
    University Paris Diderot, Sorbonne Paris Cité, Human Genetics and Cognitive Functions, 75013 Paris, France)

  • Eckart D. Gundelfinger

    (Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany)

  • Tobias M. Boeckers

    (Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany)

Abstract

Altered glutamatergic neurotransmission can lead to the core symptoms of autism, and ProSAP1/Shank2 and ProSAP2/Shank3 proteins seem to serve different interrelated functions at excitatory synapses, especially in glutamate receptor targeting/assembly.

Suggested Citation

  • Michael J. Schmeisser & Elodie Ey & Stephanie Wegener & Juergen Bockmann & A. Vanessa Stempel & Angelika Kuebler & Anna-Lena Janssen & Patrick T. Udvardi & Ehab Shiban & Christina Spilker & Detlef Bal, 2012. "Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2," Nature, Nature, vol. 486(7402), pages 256-260, June.
    • Handle: RePEc:nat:nature:v:486:y:2012:i:7402:d:10.1038_nature11015
    DOI: 10.1038/nature11015
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