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α2δ expression sets presynaptic calcium channel abundance and release probability

Author

Listed:
  • Michael B. Hoppa

    (Weill Cornell Medical College)

  • Beatrice Lana

    (Physiology and Pharmacology, Laboratory of Cellular and Molecular Neuroscience, University College London, London WC1E6BT, UK)

  • Wojciech Margas

    (Physiology and Pharmacology, Laboratory of Cellular and Molecular Neuroscience, University College London, London WC1E6BT, UK)

  • Annette C. Dolphin

    (Physiology and Pharmacology, Laboratory of Cellular and Molecular Neuroscience, University College London, London WC1E6BT, UK)

  • Timothy A. Ryan

    (Weill Cornell Medical College)

Abstract

The voltage-gated calcium channel protein subunit α2δ is shown to control both the abundance of voltage-gated calcium channels and their coupling to the vesicular release of neurotransmitters into the synapse; because the α2δ family is a known target of potent analgesics, this study offers a new link between basic synaptic physiology and pain research in the clinic.

Suggested Citation

  • Michael B. Hoppa & Beatrice Lana & Wojciech Margas & Annette C. Dolphin & Timothy A. Ryan, 2012. "α2δ expression sets presynaptic calcium channel abundance and release probability," Nature, Nature, vol. 486(7401), pages 122-125, June.
    • Handle: RePEc:nat:nature:v:486:y:2012:i:7401:d:10.1038_nature11033
    DOI: 10.1038/nature11033
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