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Genetic recombination is directed away from functional genomic elements in mice

Author

Listed:
  • Kevin Brick

    (National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892, USA)

  • Fatima Smagulova

    (Uniformed Services University of Health Sciences)

  • Pavel Khil

    (National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892, USA)

  • R. Daniel Camerini-Otero

    (National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892, USA)

  • Galina V. Petukhova

    (Uniformed Services University of Health Sciences)

Abstract

Comparison of Prdm9−/− and wild-type mice reveals a role for the PRDM9 protein in directing the recombination machinery away from important genomic regions.

Suggested Citation

  • Kevin Brick & Fatima Smagulova & Pavel Khil & R. Daniel Camerini-Otero & Galina V. Petukhova, 2012. "Genetic recombination is directed away from functional genomic elements in mice," Nature, Nature, vol. 485(7400), pages 642-645, May.
    • Handle: RePEc:nat:nature:v:485:y:2012:i:7400:d:10.1038_nature11089
    DOI: 10.1038/nature11089
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    Cited by:

    1. Úbeda, Francisco & Russell, Timothy W. & Jansen, Vincent A.A., 2019. "PRDM9 and the evolution of recombination hotspots," Theoretical Population Biology, Elsevier, vol. 126(C), pages 19-32.
    2. Adriana K. Alexander & Edward J. Rice & Jelena Lujic & Leah E. Simon & Stephanie Tanis & Gilad Barshad & Lina Zhu & Jyoti Lama & Paula E. Cohen & Charles G. Danko, 2023. "A-MYB and BRDT-dependent RNA Polymerase II pause release orchestrates transcriptional regulation in mammalian meiosis," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    3. Alexandre Nore & Ariadna B. Juarez-Martinez & Julie Clément & Christine Brun & Boubou Diagouraga & Hamida Laroussi & Corinne Grey & Henri Marc Bourbon & Jan Kadlec & Thomas Robert & Bernard Massy, 2022. "TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    4. Akbar Zainu & Pauline Dupaigne & Soumya Bouchouika & Julien Cau & Julie A. J. Clément & Pauline Auffret & Virginie Ropars & Jean-Baptiste Charbonnier & Bernard Massy & Raphael Mercier & Rajeev Kumar &, 2024. "FIGNL1-FIRRM is essential for meiotic recombination and prevents DNA damage-independent RAD51 and DMC1 loading," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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