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Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β

Author

Listed:
  • Justin M. Nussbaum

    (University of Virginia)

  • Stephan Schilling

    (Probiodrug AG, 06120 Halle (Saale), Germany)

  • Holger Cynis

    (Probiodrug AG, 06120 Halle (Saale), Germany)

  • Antonia Silva

    (University of Virginia)

  • Eric Swanson

    (University of Virginia)

  • Tanaporn Wangsanut

    (University of Virginia)

  • Kaycie Tayler

    (University of Virginia)

  • Brian Wiltgen

    (University of Virginia)

  • Asa Hatami

    (University of California at Irvine)

  • Raik Rönicke

    (Deutsches Zentrum fuer Neurodegenerative Erkrankungen, c/o Leibniz-Institut fuer Neurobiologie, 39118 Magdeburg, Germany)

  • Klaus Reymann

    (Deutsches Zentrum fuer Neurodegenerative Erkrankungen, c/o Leibniz-Institut fuer Neurobiologie, 39118 Magdeburg, Germany)

  • Birgit Hutter-Paier

    (JSW Life Sciences GmbH, A-8074 Grambach, Austria)

  • Anca Alexandru

    (Ingenium Pharmaceuticals GmbH, 82152 Munich/Martinsried, Germany)

  • Wolfgang Jagla

    (Ingenium Pharmaceuticals GmbH, 82152 Munich/Martinsried, Germany)

  • Sigrid Graubner

    (Ingenium Pharmaceuticals GmbH, 82152 Munich/Martinsried, Germany)

  • Charles G. Glabe

    (University of California at Irvine)

  • Hans-Ulrich Demuth

    (Probiodrug AG, 06120 Halle (Saale), Germany
    Ingenium Pharmaceuticals GmbH, 82152 Munich/Martinsried, Germany)

  • George S. Bloom

    (University of Virginia
    University of Virginia)

Abstract

It is shown that the formation of amyloid-β oligomers, one of the histopathological signatures of Alzheimer’s disease, can be triggered by small quantities of a specifically truncated and post-translationally modified version of amyloid-β.

Suggested Citation

  • Justin M. Nussbaum & Stephan Schilling & Holger Cynis & Antonia Silva & Eric Swanson & Tanaporn Wangsanut & Kaycie Tayler & Brian Wiltgen & Asa Hatami & Raik Rönicke & Klaus Reymann & Birgit Hutter-Pa, 2012. "Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β," Nature, Nature, vol. 485(7400), pages 651-655, May.
    • Handle: RePEc:nat:nature:v:485:y:2012:i:7400:d:10.1038_nature11060
    DOI: 10.1038/nature11060
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    Cited by:

    1. Meihua Jin & Hiroki Shiwaku & Hikari Tanaka & Takayuki Obita & Sakurako Ohuchi & Yuki Yoshioka & Xiaocen Jin & Kanoh Kondo & Kyota Fujita & Hidenori Homma & Kazuyuki Nakajima & Mineyuki Mizuguchi & Hi, 2021. "Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation," Nature Communications, Nature, vol. 12(1), pages 1-22, December.

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