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Melanoma genome sequencing reveals frequent PREX2 mutations

Author

Listed:
  • Michael F. Berger

    (The Broad Institute of Harvard and MIT
    Present address: Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA (M.F.B.); Department of Genomic Medicine, Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA (T.P.H., Y.L.D., A.P., I.R.W., M.A.S., L.C.).)

  • Eran Hodis

    (The Broad Institute of Harvard and MIT)

  • Timothy P. Heffernan

    (Dana-Farber Cancer Institute
    Present address: Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA (M.F.B.); Department of Genomic Medicine, Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA (T.P.H., Y.L.D., A.P., I.R.W., M.A.S., L.C.).)

  • Yonathan Lissanu Deribe

    (Dana-Farber Cancer Institute
    Present address: Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA (M.F.B.); Department of Genomic Medicine, Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA (T.P.H., Y.L.D., A.P., I.R.W., M.A.S., L.C.).)

  • Michael S. Lawrence

    (The Broad Institute of Harvard and MIT)

  • Alexei Protopopov

    (Dana-Farber Cancer Institute
    Present address: Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA (M.F.B.); Department of Genomic Medicine, Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA (T.P.H., Y.L.D., A.P., I.R.W., M.A.S., L.C.).)

  • Elena Ivanova

    (Dana-Farber Cancer Institute)

  • Ian R. Watson

    (Dana-Farber Cancer Institute
    Present address: Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA (M.F.B.); Department of Genomic Medicine, Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA (T.P.H., Y.L.D., A.P., I.R.W., M.A.S., L.C.).)

  • Elizabeth Nickerson

    (The Broad Institute of Harvard and MIT)

  • Papia Ghosh

    (Dana-Farber Cancer Institute)

  • Hailei Zhang

    (Dana-Farber Cancer Institute)

  • Rhamy Zeid

    (Dana-Farber Cancer Institute)

  • Xiaojia Ren

    (Dana-Farber Cancer Institute)

  • Kristian Cibulskis

    (The Broad Institute of Harvard and MIT)

  • Andrey Y. Sivachenko

    (The Broad Institute of Harvard and MIT)

  • Nikhil Wagle

    (Dana-Farber Cancer Institute
    Harvard Medical School)

  • Antje Sucker

    (University Hospital Essen, D-45122 Essen, Germany)

  • Carrie Sougnez

    (The Broad Institute of Harvard and MIT)

  • Robert Onofrio

    (The Broad Institute of Harvard and MIT)

  • Lauren Ambrogio

    (The Broad Institute of Harvard and MIT)

  • Daniel Auclair

    (The Broad Institute of Harvard and MIT)

  • Timothy Fennell

    (The Broad Institute of Harvard and MIT)

  • Scott L. Carter

    (The Broad Institute of Harvard and MIT)

  • Yotam Drier

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Petar Stojanov

    (The Broad Institute of Harvard and MIT)

  • Meredith A. Singer

    (Dana-Farber Cancer Institute
    Present address: Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA (M.F.B.); Department of Genomic Medicine, Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA (T.P.H., Y.L.D., A.P., I.R.W., M.A.S., L.C.).)

  • Douglas Voet

    (The Broad Institute of Harvard and MIT)

  • Rui Jing

    (The Broad Institute of Harvard and MIT)

  • Gordon Saksena

    (The Broad Institute of Harvard and MIT)

  • Jordi Barretina

    (The Broad Institute of Harvard and MIT)

  • Alex H. Ramos

    (The Broad Institute of Harvard and MIT
    Harvard Medical School)

  • Trevor J. Pugh

    (The Broad Institute of Harvard and MIT
    Dana-Farber Cancer Institute
    Harvard Medical School)

  • Nicolas Stransky

    (The Broad Institute of Harvard and MIT)

  • Melissa Parkin

    (The Broad Institute of Harvard and MIT)

  • Wendy Winckler

    (The Broad Institute of Harvard and MIT)

  • Scott Mahan

    (The Broad Institute of Harvard and MIT)

  • Kristin Ardlie

    (The Broad Institute of Harvard and MIT)

  • Jennifer Baldwin

    (The Broad Institute of Harvard and MIT)

  • Jennifer Wargo

    (Massachusetts General Hospital)

  • Dirk Schadendorf

    (University Hospital Essen, D-45122 Essen, Germany)

  • Matthew Meyerson

    (The Broad Institute of Harvard and MIT
    Dana-Farber Cancer Institute
    Harvard Medical School
    Center for Cancer Genome Discovery, Dana-Farber Cancer Institute)

  • Stacey B. Gabriel

    (The Broad Institute of Harvard and MIT)

  • Todd R. Golub

    (The Broad Institute of Harvard and MIT
    Center for Cancer Genome Discovery, Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Howard Hughes Medical Institute)

  • Stephan N. Wagner

    (Allergy and Infectious Diseases, Medical University of Vienna and CeMM-Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria)

  • Eric S. Lander

    (The Broad Institute of Harvard and MIT
    Whitehead Institute for Biomedical Research, 9 Cambridge Center)

  • Gad Getz

    (The Broad Institute of Harvard and MIT)

  • Lynda Chin

    (The Broad Institute of Harvard and MIT
    Dana-Farber Cancer Institute
    Harvard Medical School
    Present address: Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA (M.F.B.); Department of Genomic Medicine, Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA (T.P.H., Y.L.D., A.P., I.R.W., M.A.S., L.C.).)

  • Levi A. Garraway

    (The Broad Institute of Harvard and MIT
    Dana-Farber Cancer Institute
    Harvard Medical School
    Center for Cancer Genome Discovery, Dana-Farber Cancer Institute)

Abstract

Whole-genome sequencing of 25 metastatic melanomas and matched germline DNA in humans reveals that the highest mutation load is associated with chronic sun exposure, and that the PREX2 gene is mutated in approximately 14 per cent of cases

Suggested Citation

  • Michael F. Berger & Eran Hodis & Timothy P. Heffernan & Yonathan Lissanu Deribe & Michael S. Lawrence & Alexei Protopopov & Elena Ivanova & Ian R. Watson & Elizabeth Nickerson & Papia Ghosh & Hailei Z, 2012. "Melanoma genome sequencing reveals frequent PREX2 mutations," Nature, Nature, vol. 485(7399), pages 502-506, May.
    • Handle: RePEc:nat:nature:v:485:y:2012:i:7399:d:10.1038_nature11071
    DOI: 10.1038/nature11071
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