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Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis

Author

Listed:
  • Micheline N. Ngaki

    (Development, and Cell Biology, Iowa State University)

  • Gordon V. Louie

    (Howard Hughes Medical Institute, Jack H. Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies)

  • Ryan N. Philippe

    (Howard Hughes Medical Institute, Jack H. Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies)

  • Gerard Manning

    (Razavi Newman Center for Bioinformatics, The Salk Institute for Biological Studies)

  • Florence Pojer

    (Howard Hughes Medical Institute, Jack H. Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies)

  • Marianne E. Bowman

    (Howard Hughes Medical Institute, Jack H. Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies)

  • Ling Li

    (Development, and Cell Biology, Iowa State University)

  • Elise Larsen

    (Howard Hughes Medical Institute, Jack H. Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies)

  • Eve Syrkin Wurtele

    (Development, and Cell Biology, Iowa State University)

  • Joseph P. Noel

    (Howard Hughes Medical Institute, Jack H. Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies)

Abstract

The diffusion limited stereospecific enzyme chalcone isomerase represents the adaptive evolution of a catalytically perfected enzyme from non-catalytic, fatty-acid-binding proteins (FAPs) with contemporary roles in plant fatty-acid metabolism as evidenced by altered fatty acid content and marked reproductive defects in Arabidopsis thaliana plants bearing FAP knockouts.

Suggested Citation

  • Micheline N. Ngaki & Gordon V. Louie & Ryan N. Philippe & Gerard Manning & Florence Pojer & Marianne E. Bowman & Ling Li & Elise Larsen & Eve Syrkin Wurtele & Joseph P. Noel, 2012. "Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis," Nature, Nature, vol. 485(7399), pages 530-533, May.
    • Handle: RePEc:nat:nature:v:485:y:2012:i:7399:d:10.1038_nature11009
    DOI: 10.1038/nature11009
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