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Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic

Author

Listed:
  • Aaron A. Thompson

    (The Scripps Research Institute)

  • Wei Liu

    (The Scripps Research Institute)

  • Eugene Chun

    (The Scripps Research Institute)

  • Vsevolod Katritch

    (The Scripps Research Institute)

  • Huixian Wu

    (The Scripps Research Institute)

  • Eyal Vardy

    (National Institute of Mental Health Psychoactive Drug Screening Program, University of North Carolina Chapel Hill Medical School)

  • Xi-Ping Huang

    (National Institute of Mental Health Psychoactive Drug Screening Program, University of North Carolina Chapel Hill Medical School)

  • Claudio Trapella

    (University of Ferrara, 44121 Ferrara, Italy)

  • Remo Guerrini

    (University of Ferrara, 44121 Ferrara, Italy)

  • Girolamo Calo

    (Section of Pharmacology and National Institute of Neuroscience, University of Ferrara, 44121 Ferrara, Italy)

  • Bryan L. Roth

    (National Institute of Mental Health Psychoactive Drug Screening Program, University of North Carolina Chapel Hill Medical School)

  • Vadim Cherezov

    (The Scripps Research Institute)

  • Raymond C. Stevens

    (The Scripps Research Institute)

Abstract

The crystal structure of the human nociceptin/orphanin FQ peptide receptor in complex with the peptide mimetic antagonist compound-24 is determined, with potential importance for the development of new therapeutic agents.

Suggested Citation

  • Aaron A. Thompson & Wei Liu & Eugene Chun & Vsevolod Katritch & Huixian Wu & Eyal Vardy & Xi-Ping Huang & Claudio Trapella & Remo Guerrini & Girolamo Calo & Bryan L. Roth & Vadim Cherezov & Raymond C., 2012. "Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic," Nature, Nature, vol. 485(7398), pages 395-399, May.
    • Handle: RePEc:nat:nature:v:485:y:2012:i:7398:d:10.1038_nature11085
    DOI: 10.1038/nature11085
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