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Topological domains in mammalian genomes identified by analysis of chromatin interactions

Author

Listed:
  • Jesse R. Dixon

    (Ludwig Institute for Cancer Research, 9500 Gilman Drive
    Medical Scientist Training Program, University of California, San Diego, La Jolla, California 92093, USA
    Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, California 92093, USA)

  • Siddarth Selvaraj

    (Ludwig Institute for Cancer Research, 9500 Gilman Drive
    Bioinformatics and Systems Biology Graduate Program, University of California, San Diego, La Jolla, California 92093, USA)

  • Feng Yue

    (Ludwig Institute for Cancer Research, 9500 Gilman Drive)

  • Audrey Kim

    (Ludwig Institute for Cancer Research, 9500 Gilman Drive)

  • Yan Li

    (Ludwig Institute for Cancer Research, 9500 Gilman Drive)

  • Yin Shen

    (Ludwig Institute for Cancer Research, 9500 Gilman Drive)

  • Ming Hu

    (Harvard University, 1 Oxford Street, Cambridge, Massachusetts 02138, USA)

  • Jun S. Liu

    (Harvard University, 1 Oxford Street, Cambridge, Massachusetts 02138, USA)

  • Bing Ren

    (Ludwig Institute for Cancer Research, 9500 Gilman Drive
    University of California, San Diego School of Medicine, Institute of Genomic Medicine, UCSD Moores Cancer Center, 9500 Gilman Drive, La Jolla, California 92093, USA)

Abstract

The three-dimensional organization of the human and mouse genomes in embryonic stem cells and terminally differentiated cell types is investigated, revealing that large, megabase-sized chromatin interaction domains are a pervasive and conserved structural feature of genome organization.

Suggested Citation

  • Jesse R. Dixon & Siddarth Selvaraj & Feng Yue & Audrey Kim & Yan Li & Yin Shen & Ming Hu & Jun S. Liu & Bing Ren, 2012. "Topological domains in mammalian genomes identified by analysis of chromatin interactions," Nature, Nature, vol. 485(7398), pages 376-380, May.
    • Handle: RePEc:nat:nature:v:485:y:2012:i:7398:d:10.1038_nature11082
    DOI: 10.1038/nature11082
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