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RNF12 initiates X-chromosome inactivation by targeting REX1 for degradation

Author

Listed:
  • Cristina Gontan

    (Erasmus MC, University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands)

  • Eskeatnaf Mulugeta Achame

    (Erasmus MC, University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands)

  • Jeroen Demmers

    (Proteomics Center, Erasmus MC, University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands)

  • Tahsin Stefan Barakat

    (Erasmus MC, University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands)

  • Eveline Rentmeester

    (Erasmus MC, University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands)

  • Wilfred van IJcken

    (Erasmus MC, University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands)

  • J. Anton Grootegoed

    (Erasmus MC, University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands)

  • Joost Gribnau

    (Erasmus MC, University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands)

Abstract

The pluripotency factor REX1 is a key target of RNF12 during X-chromosome inactivation; degradation of REX1 by RNF12 leads to relief of its inhibitory action on X-chromosome inactivation.

Suggested Citation

  • Cristina Gontan & Eskeatnaf Mulugeta Achame & Jeroen Demmers & Tahsin Stefan Barakat & Eveline Rentmeester & Wilfred van IJcken & J. Anton Grootegoed & Joost Gribnau, 2012. "RNF12 initiates X-chromosome inactivation by targeting REX1 for degradation," Nature, Nature, vol. 485(7398), pages 386-390, May.
    • Handle: RePEc:nat:nature:v:485:y:2012:i:7398:d:10.1038_nature11070
    DOI: 10.1038/nature11070
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    Cited by:

    1. Milan Kumar Samanta & Srimonta Gayen & Clair Harris & Emily Maclary & Yumie Murata-Nakamura & Rebecca M. Malcore & Robert S. Porter & Patricia M. Garay & Christina N. Vallianatos & Paul B. Samollow & , 2022. "Activation of Xist by an evolutionarily conserved function of KDM5C demethylase," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Teresa Robert-Finestra & Beatrice F. Tan & Hegias Mira-Bontenbal & Erika Timmers & Cristina Gontan & Sarra Merzouk & Benedetto Daniele Giaimo & François Dossin & Wilfred F. J. IJcken & John W. M. Mart, 2021. "SPEN is required for Xist upregulation during initiation of X chromosome inactivation," Nature Communications, Nature, vol. 12(1), pages 1-13, December.

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