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A PPARγ–FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis

Author

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  • Johan W. Jonker

    (Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Present address: Center for Liver, Digestive and Metabolic Diseases, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.)

  • Jae Myoung Suh

    (Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Annette R. Atkins

    (Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Maryam Ahmadian

    (Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Pingping Li

    (University of California at San Diego)

  • Jamie Whyte

    (Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Mingxiao He

    (Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Henry Juguilon

    (Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Yun-Qiang Yin

    (Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Colin T. Phillips

    (Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Ruth T. Yu

    (Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Jerrold M. Olefsky

    (University of California at San Diego)

  • Robert R. Henry

    (University of California at San Diego
    Section of Diabetes/Metabolism, Veterans Affairs San Diego Healthcare System)

  • Michael Downes

    (Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Ronald M. Evans

    (Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Howard Hughes Medical Institute, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

Abstract

PPARγ induces fibroblast growth factor 1 to remodel visceral adipose tissue in response to a high-fat diet to maintain metabolic homeostasis.

Suggested Citation

  • Johan W. Jonker & Jae Myoung Suh & Annette R. Atkins & Maryam Ahmadian & Pingping Li & Jamie Whyte & Mingxiao He & Henry Juguilon & Yun-Qiang Yin & Colin T. Phillips & Ruth T. Yu & Jerrold M. Olefsky , 2012. "A PPARγ–FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis," Nature, Nature, vol. 485(7398), pages 391-394, May.
    • Handle: RePEc:nat:nature:v:485:y:2012:i:7398:d:10.1038_nature10998
    DOI: 10.1038/nature10998
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