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Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia

Author

Listed:
  • Catherine C. Smith

    (University of California)

  • Qi Wang

    (University of California)

  • Chen-Shan Chin

    (Pacific Biosciences)

  • Sara Salerno

    (University of California)

  • Lauren E. Damon

    (University of California)

  • Mark J. Levis

    (Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins)

  • Alexander E. Perl

    (Abramson Cancer Center of the University of Pennsylvania)

  • Kevin J. Travers

    (Pacific Biosciences)

  • Susana Wang

    (Pacific Biosciences)

  • Jeremy P. Hunt

    (Ambit Biosciences
    Present addresses: KINOMEscan Division of DiscoveRx Corporation, San Diego, California 92121, USA (J.P.H.); Blueprint Medicines Corporation, Cambridge, Massachusetts 02142, USA (P.P.Z.); Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, New York 10029, USA (E.E.S. and A.K.).)

  • Patrick P. Zarrinkar

    (Ambit Biosciences
    Present addresses: KINOMEscan Division of DiscoveRx Corporation, San Diego, California 92121, USA (J.P.H.); Blueprint Medicines Corporation, Cambridge, Massachusetts 02142, USA (P.P.Z.); Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, New York 10029, USA (E.E.S. and A.K.).)

  • Eric E. Schadt

    (Pacific Biosciences
    Present addresses: KINOMEscan Division of DiscoveRx Corporation, San Diego, California 92121, USA (J.P.H.); Blueprint Medicines Corporation, Cambridge, Massachusetts 02142, USA (P.P.Z.); Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, New York 10029, USA (E.E.S. and A.K.).)

  • Andrew Kasarskis

    (Pacific Biosciences
    Present addresses: KINOMEscan Division of DiscoveRx Corporation, San Diego, California 92121, USA (J.P.H.); Blueprint Medicines Corporation, Cambridge, Massachusetts 02142, USA (P.P.Z.); Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, New York 10029, USA (E.E.S. and A.K.).)

  • John Kuriyan

    (University of California)

  • Neil P. Shah

    (University of California
    Helen Diller Family Comprehensive Cancer Center, University of California)

Abstract

Internal tandem duplication mutations in FLT3, known to be associated with a poor prognosis in acute myeloid leukaemia, are now shown to be a valid therapeutic target for the disease.

Suggested Citation

  • Catherine C. Smith & Qi Wang & Chen-Shan Chin & Sara Salerno & Lauren E. Damon & Mark J. Levis & Alexander E. Perl & Kevin J. Travers & Susana Wang & Jeremy P. Hunt & Patrick P. Zarrinkar & Eric E. Sc, 2012. "Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia," Nature, Nature, vol. 485(7397), pages 260-263, May.
    • Handle: RePEc:nat:nature:v:485:y:2012:i:7397:d:10.1038_nature11016
    DOI: 10.1038/nature11016
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    Citations

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    Cited by:

    1. Ravi K Patel & Mark C Weir & Kexin Shen & Daniel Snyder & Vaughn S Cooper & Thomas E Smithgall, 2019. "Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance," PLOS ONE, Public Library of Science, vol. 14(12), pages 1-29, December.
    2. Keith Woodley & Laura S. Dillingh & George Giotopoulos & Pedro Madrigal & Kevin M. Rattigan & Céline Philippe & Vilma Dembitz & Aoife M. S. Magee & Ryan Asby & Louie N. van de Lagemaat & Christopher M, 2023. "Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Benjamin J. Huang & Jenny L. Smith & Jason E. Farrar & Yi-Cheng Wang & Masayuki Umeda & Rhonda E. Ries & Amanda R. Leonti & Erin Crowgey & Scott N. Furlan & Katherine Tarlock & Marcos Armendariz & Yan, 2022. "Integrated stem cell signature and cytomolecular risk determination in pediatric acute myeloid leukemia," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    4. Hanlin Wang & Guanghao Luo & Xiaobei Hu & Gaoya Xu & Tao Wang & Minmin Liu & Xiaohui Qiu & Jianan Li & Jingfeng Fu & Bo Feng & Yutong Tu & Weijuan Kan & Chang Wang & Ran Xu & Yubo Zhou & Jianmin Yang , 2023. "Targeting C/EBPα overcomes primary resistance and improves the efficacy of FLT3 inhibitors in acute myeloid leukaemia," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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