IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v485y2012i7397d10.1038_nature11013.html
   My bibliography  Save this article

Systematic discovery of structural elements governing stability of mammalian messenger RNAs

Author

Listed:
  • Hani Goodarzi

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Princeton University
    Present addresses: Department of Biochemistry and Molecular Biophysics, and Initiative in Systems Biology, Columbia University, New York, New York 10032, USA (H.G., P.O., S.T.); The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada (H.S.N.).)

  • Hamed S. Najafabadi

    (Institute of Parasitology, McGill University, Montreal, Quebec H3G1Y6, Canada
    McGill Centre for Bioinformatics, McGill University, Montreal, Quebec H3G1Y6, Canada
    Present addresses: Department of Biochemistry and Molecular Biophysics, and Initiative in Systems Biology, Columbia University, New York, New York 10032, USA (H.G., P.O., S.T.); The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada (H.S.N.).)

  • Panos Oikonomou

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Princeton University
    Present addresses: Department of Biochemistry and Molecular Biophysics, and Initiative in Systems Biology, Columbia University, New York, New York 10032, USA (H.G., P.O., S.T.); The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada (H.S.N.).)

  • Todd M. Greco

    (Princeton University)

  • Lisa Fish

    (Laboratory of Systems Cancer Biology, Rockefeller University)

  • Reza Salavati

    (Institute of Parasitology, McGill University, Montreal, Quebec H3G1Y6, Canada
    McGill Centre for Bioinformatics, McGill University, Montreal, Quebec H3G1Y6, Canada
    McGill University, Montreal, Quebec H3G1Y6, Canada)

  • Ileana M. Cristea

    (Princeton University)

  • Saeed Tavazoie

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Princeton University
    Present addresses: Department of Biochemistry and Molecular Biophysics, and Initiative in Systems Biology, Columbia University, New York, New York 10032, USA (H.G., P.O., S.T.); The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada (H.S.N.).)

Abstract

Secondary structures, or pairing of complementary sequences within RNA, can regulate the binding of proteins that affect transcript stability, splicing, localization, and translation; a computational approach has now been used to discover secondary structures that affect global RNA stability through the binding of specific RNA binding proteins.

Suggested Citation

  • Hani Goodarzi & Hamed S. Najafabadi & Panos Oikonomou & Todd M. Greco & Lisa Fish & Reza Salavati & Ileana M. Cristea & Saeed Tavazoie, 2012. "Systematic discovery of structural elements governing stability of mammalian messenger RNAs," Nature, Nature, vol. 485(7397), pages 264-268, May.
    • Handle: RePEc:nat:nature:v:485:y:2012:i:7397:d:10.1038_nature11013
    DOI: 10.1038/nature11013
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature11013
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature11013?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Xiaofei Yang & Haopeng Yu & Susan Duncan & Yueying Zhang & Jitender Cheema & Haifeng Liu & J. Benjamin Miller & Jie Zhang & Chun Kit Kwok & Huakun Zhang & Yiliang Ding, 2022. "RNA G-quadruplex structure contributes to cold adaptation in plants," Nature Communications, Nature, vol. 13(1), pages 1-9, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:485:y:2012:i:7397:d:10.1038_nature11013. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.