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Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

Author

Listed:
  • Han Cho

    (Gene Expression Laboratory, Salk Institute for Biological Studies)

  • Xuan Zhao

    (Gene Expression Laboratory, Salk Institute for Biological Studies)

  • Megumi Hatori

    (Regulatory Biology Laboratory, Salk Institute for Biological Studies)

  • Ruth T. Yu

    (Gene Expression Laboratory, Salk Institute for Biological Studies)

  • Grant D. Barish

    (Gene Expression Laboratory, Salk Institute for Biological Studies)

  • Michael T. Lam

    (School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA)

  • Ling-Wa Chong

    (Gene Expression Laboratory, Salk Institute for Biological Studies)

  • Luciano DiTacchio

    (Regulatory Biology Laboratory, Salk Institute for Biological Studies)

  • Annette R. Atkins

    (Gene Expression Laboratory, Salk Institute for Biological Studies)

  • Christopher K. Glass

    (School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA)

  • Christopher Liddle

    (The Storr Liver Unit, Westmead Millennium Institute and University of Sydney, Westmead Hospital)

  • Johan Auwerx

    (Ecole Polytechnique Fédérale in Lausanne CH-1015)

  • Michael Downes

    (Gene Expression Laboratory, Salk Institute for Biological Studies)

  • Satchidananda Panda

    (Regulatory Biology Laboratory, Salk Institute for Biological Studies)

  • Ronald M. Evans

    (Gene Expression Laboratory, Salk Institute for Biological Studies
    Howard Hughes Medical Institute, Salk Institute for Biological Studies)

Abstract

The nuclear receptors REV-ERB-α and REV-ERB-β are indispensible for the coordination of circadian rhythm and metabolism; mice without these nuclear receptors show disrupted circadian expression of core circadian clock and lipid homeostatic gene networks.

Suggested Citation

  • Han Cho & Xuan Zhao & Megumi Hatori & Ruth T. Yu & Grant D. Barish & Michael T. Lam & Ling-Wa Chong & Luciano DiTacchio & Annette R. Atkins & Christopher K. Glass & Christopher Liddle & Johan Auwerx &, 2012. "Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β," Nature, Nature, vol. 485(7396), pages 123-127, May.
    • Handle: RePEc:nat:nature:v:485:y:2012:i:7396:d:10.1038_nature11048
    DOI: 10.1038/nature11048
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    Citations

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    Cited by:

    1. Rongfeng Huang & Jianghui Chen & Meiyu Zhou & Haoran Xin & Sin Man Lam & Xiaoqing Jiang & Jie Li & Fang Deng & Guanghou Shui & Zhihui Zhang & Min-Dian Li, 2023. "Multi-omics profiling reveals rhythmic liver function shaped by meal timing," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Meghan H. Murray & Aurore Cecile Valfort & Thomas Koelblen & Céline Ronin & Fabrice Ciesielski & Arindam Chatterjee & Giri Babu Veerakanellore & Bahaa Elgendy & John K. Walker & Lamees Hegazy & Thomas, 2022. "Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Qixin Wang & Isaac Kirubakaran Sundar & Joseph H. Lucas & Jun-Gyu Park & Aitor Nogales & Luis Martinez-Sobrido & Irfan Rahman, 2023. "Circadian clock molecule REV-ERBα regulates lung fibrotic progression through collagen stabilization," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. Yasuko O. Abe & Hikari Yoshitane & Dae Wook Kim & Satoshi Kawakami & Michinori Koebis & Kazuki Nakao & Atsu Aiba & Jae Kyoung Kim & Yoshitaka Fukada, 2022. "Rhythmic transcription of Bmal1 stabilizes the circadian timekeeping system in mammals," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    5. Li, Ying & Liu, Zengrong, 2015. "Dynamical mechanism of Bmal1/Rev-erbα loop in circadian clock," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 430(C), pages 126-135.

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