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Evidence of non-random mutation rates suggests an evolutionary risk management strategy

Author

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  • Iñigo Martincorena

    (EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK)

  • Aswin S. N. Seshasayee

    (EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK
    Present address: National Centre for Biological Sciences, TIFR, GKVK, Bellary Road, Bangalore 560065, India.)

  • Nicholas M. Luscombe

    (EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK
    Okinawa Institute of Science & Technology, 1919-1 Tancha, Onna-son, Kunigami-gun, Okinawa 904-0495, Japan
    UCL Genetics Institute, Environment and Evolution, University College London, Gower Street, London WC1E 6BT, UK
    Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK)

Abstract

The local mutation rate in Escherichia coli has evolved to reduce the risk of deleterious mutations, leading to a non-random occurrence of mutations and suggesting that DNA protection and repair mechanisms preferentially target more important genes.

Suggested Citation

  • Iñigo Martincorena & Aswin S. N. Seshasayee & Nicholas M. Luscombe, 2012. "Evidence of non-random mutation rates suggests an evolutionary risk management strategy," Nature, Nature, vol. 485(7396), pages 95-98, May.
    • Handle: RePEc:nat:nature:v:485:y:2012:i:7396:d:10.1038_nature10995
    DOI: 10.1038/nature10995
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    Cited by:

    1. Saakian, David B. & Ghazaryan, Makar & Bratus, Alexander & Hu, Chin-Kun, 2017. "Biological evolution model with conditional mutation rates," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 474(C), pages 32-38.

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