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Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes

Author

Listed:
  • Yiguo Wang

    (Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Gang Li

    (Columbia University)

  • Jason Goode

    (Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Jose C. Paz

    (Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Kunfu Ouyang

    (University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Robert Screaton

    (Children’s Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa, Ontario K1H 8L1, Canada
    University of Ottawa, Ottawa, Ontario K1H 8L1, Canada
    University of Ottawa, Ottawa, Ontario K1H 8L1, Canada)

  • Wolfgang H. Fischer

    (Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Ju Chen

    (University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Ira Tabas

    (Columbia University
    Columbia University
    Columbia University)

  • Marc Montminy

    (Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

Abstract

Interactions between cyclic AMP and calcium signalling pathways mediated by the inositol 1,4,5-trisphosphate receptor are shown to regulate hepatic gluconeogenesis in fasting and diabetes.

Suggested Citation

  • Yiguo Wang & Gang Li & Jason Goode & Jose C. Paz & Kunfu Ouyang & Robert Screaton & Wolfgang H. Fischer & Ju Chen & Ira Tabas & Marc Montminy, 2012. "Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes," Nature, Nature, vol. 485(7396), pages 128-132, May.
    • Handle: RePEc:nat:nature:v:485:y:2012:i:7396:d:10.1038_nature10988
    DOI: 10.1038/nature10988
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