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Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia

Author

Listed:
  • George T. Eisenhoffer

    (Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope Drive, Salt Lake City, Utah 84112, USA)

  • Patrick D. Loftus

    (Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope Drive, Salt Lake City, Utah 84112, USA)

  • Masaaki Yoshigi

    (University of Utah, 295 Chipeta Way RM 2S010, Salt Lake City, Utah 84108, USA)

  • Hideo Otsuna

    (University of Utah, 401 MREB, 20N 1900E, Salt Lake City, Utah 84132, USA)

  • Chi-Bin Chien

    (University of Utah, 401 MREB, 20N 1900E, Salt Lake City, Utah 84132, USA)

  • Paul A. Morcos

    (Gene Tools, LLC, 1001 Summerton Way, Philmath, Oregon 97370, USA)

  • Jody Rosenblatt

    (Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope Drive, Salt Lake City, Utah 84112, USA)

Abstract

Here it is shown that epithelia extrude live but not dying cells at sites of high strain, elucidating a mechanism for maintaining homeostatic cell numbers.

Suggested Citation

  • George T. Eisenhoffer & Patrick D. Loftus & Masaaki Yoshigi & Hideo Otsuna & Chi-Bin Chien & Paul A. Morcos & Jody Rosenblatt, 2012. "Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia," Nature, Nature, vol. 484(7395), pages 546-549, April.
    • Handle: RePEc:nat:nature:v:484:y:2012:i:7395:d:10.1038_nature10999
    DOI: 10.1038/nature10999
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    Cited by:

    1. Guilherme Ventura & Aboutaleb Amiri & Raghavan Thiagarajan & Mari Tolonen & Amin Doostmohammadi & Jakub Sedzinski, 2022. "Multiciliated cells use filopodia to probe tissue mechanics during epithelial integration in vivo," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. John Fadul & Teresa Zulueta-Coarasa & Gloria M. Slattum & Nadja M. Redd & Mauricio Franco Jin & Michael J. Redd & Stephan Daetwyler & Danielle Hedeen & Jan Huisken & Jody Rosenblatt, 2021. "KRas-transformed epithelia cells invade and partially dedifferentiate by basal cell extrusion," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    3. Sine Yaganoglu & Konstantinos Kalyviotis & Christina Vagena-Pantoula & Dörthe Jülich & Benjamin M. Gaub & Maaike Welling & Tatiana Lopes & Dariusz Lachowski & See Swee Tang & Armando Del Rio Hernandez, 2023. "Highly specific and non-invasive imaging of Piezo1-dependent activity across scales using GenEPi," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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