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Live-cell delamination counterbalances epithelial growth to limit tissue overcrowding

Author

Listed:
  • Eliana Marinari

    (Medical Research Council Laboratory of Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK)

  • Aida Mehonic

    (University College London, Gower Street, London WC1E 6BT, UK)

  • Scott Curran

    (Medical Research Council Laboratory of Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK)

  • Jonathan Gale

    (UCL Ear Institute, University College London, 332 Gray’s Inn Road, London WC1X 8EE, UK)

  • Thomas Duke

    (University College London, Gower Street, London WC1E 6BT, UK)

  • Buzz Baum

    (Medical Research Council Laboratory of Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK)

Abstract

To maintain homeostasis in epithelial cell layers in Drosophila, cell overcrowding causes a proportion of cells to undergo a loss of cell adhesive junctions and be squeezed out by neighbouring cells.

Suggested Citation

  • Eliana Marinari & Aida Mehonic & Scott Curran & Jonathan Gale & Thomas Duke & Buzz Baum, 2012. "Live-cell delamination counterbalances epithelial growth to limit tissue overcrowding," Nature, Nature, vol. 484(7395), pages 542-545, April.
    • Handle: RePEc:nat:nature:v:484:y:2012:i:7395:d:10.1038_nature10984
    DOI: 10.1038/nature10984
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    Cited by:

    1. Ernest C Y Ho & Juan Nicolas Malagón & Abha Ahuja & Rama Singh & Ellen Larsen, 2018. "Rotation of sex combs in Drosophila melanogaster requires precise and coordinated spatio-temporal dynamics from forces generated by epithelial cells," PLOS Computational Biology, Public Library of Science, vol. 14(10), pages 1-28, October.
    2. Alexis Villars & Alexis Matamoro-Vidal & Florence Levillayer & Romain Levayer, 2022. "Microtubule disassembly by caspases is an important rate-limiting step of cell extrusion," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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