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Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’

Author

Listed:
  • Aron M. Levin

    (Howard Hughes Medical Institute, Stanford University School of Medicine)

  • Darren L. Bates

    (Stanford University School of Medicine)

  • Aaron M. Ring

    (Stanford University School of Medicine)

  • Carsten Krieg

    (Laboratory of Applied Immunobiology, University of Zurich, Zurich CH-8006, Switzerland
    Allergy Unit, University Hospital Zurich, Zurich CH-8091, Switzerland)

  • Jack T. Lin

    (Stanford University School of Medicine, Stanford, California 94305, USA)

  • Leon Su

    (Stanford University School of Medicine, Stanford, California 94305, USA)

  • Ignacio Moraga

    (Stanford University School of Medicine)

  • Miro E. Raeber

    (Laboratory of Applied Immunobiology, University of Zurich, Zurich CH-8006, Switzerland
    Allergy Unit, University Hospital Zurich, Zurich CH-8091, Switzerland)

  • Gregory R. Bowman

    (Stanford University)

  • Paul Novick

    (Stanford University)

  • Vijay S. Pande

    (Stanford University)

  • C. Garrison Fathman

    (Stanford University School of Medicine, Stanford, California 94305, USA)

  • Onur Boyman

    (Laboratory of Applied Immunobiology, University of Zurich, Zurich CH-8006, Switzerland
    Allergy Unit, University Hospital Zurich, Zurich CH-8091, Switzerland)

  • K. Christopher Garcia

    (Howard Hughes Medical Institute, Stanford University School of Medicine
    Stanford University School of Medicine)

Abstract

Although IL-2 has been studied for its immune-stimulating activity against metastatic cancer, its side effects have limited its clinical use; here, an engineered IL-2 ‘superkine’ is shown to have increased activity, particularly in inducing antitumour T cells, but fewer side effects.

Suggested Citation

  • Aron M. Levin & Darren L. Bates & Aaron M. Ring & Carsten Krieg & Jack T. Lin & Leon Su & Ignacio Moraga & Miro E. Raeber & Gregory R. Bowman & Paul Novick & Vijay S. Pande & C. Garrison Fathman & Onu, 2012. "Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’," Nature, Nature, vol. 484(7395), pages 529-533, April.
    • Handle: RePEc:nat:nature:v:484:y:2012:i:7395:d:10.1038_nature10975
    DOI: 10.1038/nature10975
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