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Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β

Author

Listed:
  • Christina E. Zielinski

    (Institute for Research in Biomedicine
    Present address: Department of Dermatology and Berlin-Brandenburg School for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Germany.)

  • Federico Mele

    (Institute for Research in Biomedicine)

  • Dominik Aschenbrenner

    (Institute for Research in Biomedicine)

  • David Jarrossay

    (Institute for Research in Biomedicine)

  • Francesca Ronchi

    (Institute for Research in Biomedicine)

  • Marco Gattorno

    (“G. Gaslini” Scientific Institute, Largo G. Gaslini 5, 16147, Genova, Italy)

  • Silvia Monticelli

    (Institute for Research in Biomedicine)

  • Antonio Lanzavecchia

    (Institute for Research in Biomedicine
    Institute of Microbiology, ETH Zurich)

  • Federica Sallusto

    (Institute for Research in Biomedicine)

Abstract

Infection with Candida albicans and Staphylococcus aureus gives rise to TH17 cells with different properties; microbe-induced T-cell differentiation is shown here to depend on the balance between polarizing cytokines rather than absolute amounts.

Suggested Citation

  • Christina E. Zielinski & Federico Mele & Dominik Aschenbrenner & David Jarrossay & Francesca Ronchi & Marco Gattorno & Silvia Monticelli & Antonio Lanzavecchia & Federica Sallusto, 2012. "Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β," Nature, Nature, vol. 484(7395), pages 514-518, April.
    • Handle: RePEc:nat:nature:v:484:y:2012:i:7395:d:10.1038_nature10957
    DOI: 10.1038/nature10957
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    Cited by:

    1. Jonas Engesser & Robin Khatri & Darius P. Schaub & Yu Zhao & Hans-Joachim Paust & Zeba Sultana & Nariaki Asada & Jan-Hendrik Riedel & Varshi Sivayoganathan & Anett Peters & Anna Kaffke & Saskia-Lariss, 2024. "Immune profiling-based targeting of pathogenic T cells with ustekinumab in ANCA-associated glomerulonephritis," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Katrin Vogel & Aditya Arra & Holger Lingel & Dirk Bretschneider & Florian Prätsch & Denny Schanze & Martin Zenker & Silke Balk & Dunja Bruder & Robert Geffers & Thomas Hachenberg & Christoph Arens & M, 2023. "Bifidobacteria shape antimicrobial T-helper cell responses during infancy and adulthood," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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