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IFITM3 restricts the morbidity and mortality associated with influenza

Author

Listed:
  • Aaron R. Everitt

    (Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK)

  • Simon Clare

    (Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK)

  • Thomas Pertel

    (Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University)

  • Sinu P. John

    (Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University)

  • Rachael S. Wash

    (Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK)

  • Sarah E. Smith

    (Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK)

  • Christopher R. Chin

    (Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University)

  • Eric M. Feeley

    (Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University)

  • Jennifer S. Sims

    (Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University)

  • David J. Adams

    (Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK)

  • Helen M. Wise

    (Divison of Virology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK)

  • Leanne Kane

    (Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK)

  • David Goulding

    (Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK)

  • Paul Digard

    (Divison of Virology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK)

  • Verneri Anttila

    (Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK)

  • J. Kenneth Baillie

    (The Roslin Institute, University of Edinburgh, Roslin EH25 9RG, UK
    University of Edinburgh, Edinburgh EH16 4TJ, UK)

  • Tim S. Walsh

    (University of Edinburgh, Edinburgh EH16 4TJ, UK)

  • David A. Hume

    (The Roslin Institute, University of Edinburgh, Roslin EH25 9RG, UK)

  • Aarno Palotie

    (Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK)

  • Yali Xue

    (Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK)

  • Vincenza Colonna

    (Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
    Institute of Genetics and Biophysics “A. Buzzati-Traverso”)

  • Chris Tyler-Smith

    (Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK)

  • Jake Dunning

    (Centre for Respiratory Infection, National Heart and Lung Institute, St Mary’s Campus, Imperial College London, W2 1PG, UK)

  • Stephen B. Gordon

    (Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK)

  • Rosalind L. Smyth

    (Institute of Translational Medicine, University of Liverpool, Alder Hey Children’s Hospital, Liverpool L12 2AP, UK)

  • Peter J. Openshaw

    (Centre for Respiratory Infection, National Heart and Lung Institute, St Mary’s Campus, Imperial College London, W2 1PG, UK)

  • Gordon Dougan

    (Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK)

  • Abraham L. Brass

    (Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University
    Gastrointestinal Unit, Massachusetts General Hospital)

  • Paul Kellam

    (Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
    UCL/MRC Centre for Medical Molecular Virology, University College London, Cleveland Street, London W1T 4JF, UK)

Abstract

Interferon-inducible transmembrane (IFITM) protein 3 is shown to be an innate defence mechanism against viral infection in vivo; furthermore, a subset of the patients hospitalized during the H1N1 2009 pandemic carried a variant form of the IFITM3 gene.

Suggested Citation

  • Aaron R. Everitt & Simon Clare & Thomas Pertel & Sinu P. John & Rachael S. Wash & Sarah E. Smith & Christopher R. Chin & Eric M. Feeley & Jennifer S. Sims & David J. Adams & Helen M. Wise & Leanne Kan, 2012. "IFITM3 restricts the morbidity and mortality associated with influenza," Nature, Nature, vol. 484(7395), pages 519-523, April.
    • Handle: RePEc:nat:nature:v:484:y:2012:i:7395:d:10.1038_nature10921
    DOI: 10.1038/nature10921
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    Citations

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    Cited by:

    1. Parker J. Denz & Samuel Speaks & Adam D. Kenney & Adrian C. Eddy & Jonathan L. Papa & Jack Roettger & Sydney C. Scace & Adam Rubrum & Emily A. Hemann & Adriana Forero & Richard J. Webby & Andrew S. Bo, 2024. "Innate immune control of influenza virus interspecies adaptation via IFITM3," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    2. M. Clement & J. L. Forbester & M. Marsden & P. Sabberwal & M. S. Sommerville & D. Wellington & S. Dimonte & S. Clare & K. Harcourt & Z. Yin & L. Nobre & R. Antrobus & B. Jin & M. Chen & S. Makvandi-Ne, 2022. "IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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