IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v484y2012i7394d10.1038_nature10980.html
   My bibliography  Save this article

Hsp72 preserves muscle function and slows progression of severe muscular dystrophy

Author

Listed:
  • Stefan M. Gehrig

    (Basic and Clinical Myology Laboratory, University of Melbourne)

  • Chris van der Poel

    (Basic and Clinical Myology Laboratory, University of Melbourne
    Present addresses: Department of Human Biosciences, Faculty of Health Sciences, La Trobe University, Bundoora, 3086, Victoria, Australia (C.v.d.P. and J.E.C.); Department of Biochemistry and Biomedical Sciences and Department of Pediatrics, McMaster University, Hamilton, Ontario, L8S 4L8, Canada (J.D.S.).)

  • Timothy A. Sayer

    (Basic and Clinical Myology Laboratory, University of Melbourne)

  • Jonathan D. Schertzer

    (Basic and Clinical Myology Laboratory, University of Melbourne
    Present addresses: Department of Human Biosciences, Faculty of Health Sciences, La Trobe University, Bundoora, 3086, Victoria, Australia (C.v.d.P. and J.E.C.); Department of Biochemistry and Biomedical Sciences and Department of Pediatrics, McMaster University, Hamilton, Ontario, L8S 4L8, Canada (J.D.S.).)

  • Darren C. Henstridge

    (Cellular and Molecular Metabolism Laboratory, Baker-IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Victoria, 8008, Australia)

  • Jarrod E. Church

    (Basic and Clinical Myology Laboratory, University of Melbourne
    Present addresses: Department of Human Biosciences, Faculty of Health Sciences, La Trobe University, Bundoora, 3086, Victoria, Australia (C.v.d.P. and J.E.C.); Department of Biochemistry and Biomedical Sciences and Department of Pediatrics, McMaster University, Hamilton, Ontario, L8S 4L8, Canada (J.D.S.).)

  • Severine Lamon

    (Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, 3125, Australia)

  • Aaron P. Russell

    (Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, 3125, Australia)

  • Kay E. Davies

    (MRC Functional Genomics Unit, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK)

  • Mark A. Febbraio

    (Cellular and Molecular Metabolism Laboratory, Baker-IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Victoria, 8008, Australia)

  • Gordon S. Lynch

    (Basic and Clinical Myology Laboratory, University of Melbourne)

Abstract

Increasing the expression of intramuscular heat shock protein 72 preserves muscle strength and ameliorates the dystrophic pathology in two mouse models of muscular dystrophy, suggesting a promising way forward for the treatment of muscular dystrophy.

Suggested Citation

  • Stefan M. Gehrig & Chris van der Poel & Timothy A. Sayer & Jonathan D. Schertzer & Darren C. Henstridge & Jarrod E. Church & Severine Lamon & Aaron P. Russell & Kay E. Davies & Mark A. Febbraio & Gord, 2012. "Hsp72 preserves muscle function and slows progression of severe muscular dystrophy," Nature, Nature, vol. 484(7394), pages 394-398, April.
    • Handle: RePEc:nat:nature:v:484:y:2012:i:7394:d:10.1038_nature10980
    DOI: 10.1038/nature10980
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature10980
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature10980?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ronja Schiemann & Annika Buhr & Eva Cordes & Stefan Walter & Jürgen J. Heinisch & Paola Ferrero & Hendrik Milting & Achim Paululat & Heiko Meyer, 2022. "Neprilysins regulate muscle contraction and heart function via cleavage of SERCA-inhibitory micropeptides," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:484:y:2012:i:7394:d:10.1038_nature10980. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.