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DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation

Author

Listed:
  • Pierre Close

    (Mechanisms of Transcription Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms EN6 3LD, UK
    Unit of Medical Chemistry, GIGA-Signal Transduction, GIGA-R, University of Liege, CHU, Sart-Tilman, 4000 Liege, Belgium)

  • Philip East

    (Bioinformatics & Biostatistics Group, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK)

  • A. Barbara Dirac-Svejstrup

    (Mechanisms of Transcription Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms EN6 3LD, UK)

  • Holger Hartmann

    (Gene Center and Center for Integrated Protein Science Munich (CIPSM), Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, 81377 Munich, Germany)

  • Mark Heron

    (Gene Center and Center for Integrated Protein Science Munich (CIPSM), Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, 81377 Munich, Germany)

  • Sarah Maslen

    (Protein Analysis and Proteomics Laboratory, Clare Hall Laboratories, Cancer Research UK, London Research Institute, South Mimms EN6 3LD, UK)

  • Alain Chariot

    (Unit of Medical Chemistry, GIGA-Signal Transduction, GIGA-R, University of Liege, CHU, Sart-Tilman, 4000 Liege, Belgium)

  • Johannes Söding

    (Gene Center and Center for Integrated Protein Science Munich (CIPSM), Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, 81377 Munich, Germany)

  • Mark Skehel

    (Protein Analysis and Proteomics Laboratory, Clare Hall Laboratories, Cancer Research UK, London Research Institute, South Mimms EN6 3LD, UK)

  • Jesper Q. Svejstrup

    (Mechanisms of Transcription Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms EN6 3LD, UK)

Abstract

Characterization of the human interactome of chromatin-associated messenger ribonucleoprotein particles identifies DBC1 and a new protein (ZIRD) as subunits of a protein complex (DBIRD) that binds directly to RNAPII, regulates alternative splicing of exons embedded in (A + T)-rich DNA, and whose depletion results in region-specific decreases in transcript elongation.

Suggested Citation

  • Pierre Close & Philip East & A. Barbara Dirac-Svejstrup & Holger Hartmann & Mark Heron & Sarah Maslen & Alain Chariot & Johannes Söding & Mark Skehel & Jesper Q. Svejstrup, 2012. "DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation," Nature, Nature, vol. 484(7394), pages 386-389, April.
    • Handle: RePEc:nat:nature:v:484:y:2012:i:7394:d:10.1038_nature10925
    DOI: 10.1038/nature10925
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    Cited by:

    1. Lisa-Marie Appel & Vedran Franke & Melania Bruno & Irina Grishkovskaya & Aiste Kasiliauskaite & Tanja Kaufmann & Ursula E. Schoeberl & Martin G. Puchinger & Sebastian Kostrhon & Carmen Ebenwaldner & M, 2021. "PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC," Nature Communications, Nature, vol. 12(1), pages 1-24, December.

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