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Telomerase RNA biogenesis involves sequential binding by Sm and Lsm complexes

Author

Listed:
  • Wen Tang

    (Howard Hughes Medical Institute
    Stowers Institute for Medical Research
    University of Kansas Medical Center, Kansas City)

  • Ram Kannan

    (Howard Hughes Medical Institute
    Stowers Institute for Medical Research
    University of Kansas Medical Center, Kansas City)

  • Marco Blanchette

    (Stowers Institute for Medical Research
    University of Kansas Medical Center)

  • Peter Baumann

    (Howard Hughes Medical Institute
    Stowers Institute for Medical Research
    University of Kansas Medical Center, Kansas City)

Abstract

Two complexes of RNA-binding proteins, Sm and Lsm2–8, act sequentially on telomerase RNA during its biogenesis: the Sm ring promotes 3′-cleavage and facilitates hypermethylation of the 5′-cap, whereas the Lsm2–8 complex aids binding of the telomerase catalytic subunit and prevents degradation of the RNA.

Suggested Citation

  • Wen Tang & Ram Kannan & Marco Blanchette & Peter Baumann, 2012. "Telomerase RNA biogenesis involves sequential binding by Sm and Lsm complexes," Nature, Nature, vol. 484(7393), pages 260-264, April.
    • Handle: RePEc:nat:nature:v:484:y:2012:i:7393:d:10.1038_nature10924
    DOI: 10.1038/nature10924
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    Cited by:

    1. Jennifer Porat & Moaine El Baidouri & Jorg Grigull & Jean-Marc Deragon & Mark A. Bayfield, 2022. "The methyl phosphate capping enzyme Bmc1/Bin3 is a stable component of the fission yeast telomerase holoenzyme," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Diego J. Páez-Moscoso & David V. Ho & Lili Pan & Katie Hildebrand & Kristi L. Jensen & Michaella J. Levy & Laurence Florens & Peter Baumann, 2022. "A putative cap binding protein and the methyl phosphate capping enzyme Bin3/MePCE function in telomerase biogenesis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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