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Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy

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  • Yujie Cui

    (Molecular Cardiology, Nephrology and Hypertension, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Present address: School of Laboratory Science, Tianjin Medical University, Tianjin 300203, China (Y.C.); Department of Cardiology, Peking Union Medical College, Beijing 100730, China (W.W.); Lee Kong Chian School of Medicine, Singapore 637553 (D.K.S.).)

  • Wei Wang

    (Molecular Cardiology, Nephrology and Hypertension, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Present address: School of Laboratory Science, Tianjin Medical University, Tianjin 300203, China (Y.C.); Department of Cardiology, Peking Union Medical College, Beijing 100730, China (W.W.); Lee Kong Chian School of Medicine, Singapore 637553 (D.K.S.).)

  • Ningzheng Dong

    (Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, 199 Ren Ai Road, Suzhou 215123, China
    Key Lab of Thrombosis and Hemostasis, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, 188 Shi Zhi Street, Suzhou 215006, China)

  • Jinglei Lou

    (Molecular Cardiology, Nephrology and Hypertension, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA)

  • Dinesh Kumar Srinivasan

    (Molecular Cardiology, Nephrology and Hypertension, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Present address: School of Laboratory Science, Tianjin Medical University, Tianjin 300203, China (Y.C.); Department of Cardiology, Peking Union Medical College, Beijing 100730, China (W.W.); Lee Kong Chian School of Medicine, Singapore 637553 (D.K.S.).)

  • Weiwei Cheng

    (The International Peace Maternity and Child Health Hospital, Shanghai Jiaotong University School of Medicine, 910 Hengshan Road, Shanghai 200030, China)

  • Xiaoyi Huang

    (The International Peace Maternity and Child Health Hospital, Shanghai Jiaotong University School of Medicine, 910 Hengshan Road, Shanghai 200030, China)

  • Meng Liu

    (Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, 199 Ren Ai Road, Suzhou 215123, China)

  • Chaodong Fang

    (Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, 199 Ren Ai Road, Suzhou 215123, China)

  • Jianhao Peng

    (Molecular Cardiology, Nephrology and Hypertension, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA)

  • Shenghan Chen

    (Molecular Cardiology, Nephrology and Hypertension, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA)

  • Shannon Wu

    (Molecular Cardiology, Nephrology and Hypertension, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA)

  • Zhenzhen Liu

    (Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, 199 Ren Ai Road, Suzhou 215123, China)

  • Liang Dong

    (Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, 199 Ren Ai Road, Suzhou 215123, China)

  • Yiqing Zhou

    (Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, 199 Ren Ai Road, Suzhou 215123, China)

  • Qingyu Wu

    (Molecular Cardiology, Nephrology and Hypertension, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, 199 Ren Ai Road, Suzhou 215123, China)

Abstract

Pregnant corin- or ANP-deficient mice have impaired trophoblast invasion and uterine spiral artery remodelling, and patients with pre-eclampsia have lower uterine corin messenger RNA and protein levels than normal pregnancies, suggesting that defects in corin and ANP function may contribute to pre-eclampsia.

Suggested Citation

  • Yujie Cui & Wei Wang & Ningzheng Dong & Jinglei Lou & Dinesh Kumar Srinivasan & Weiwei Cheng & Xiaoyi Huang & Meng Liu & Chaodong Fang & Jianhao Peng & Shenghan Chen & Shannon Wu & Zhenzhen Liu & Lian, 2012. "Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy," Nature, Nature, vol. 484(7393), pages 246-250, April.
    • Handle: RePEc:nat:nature:v:484:y:2012:i:7393:d:10.1038_nature10897
    DOI: 10.1038/nature10897
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