IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v484y2012i7392d10.1038_nature10908.html
   My bibliography  Save this article

Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF–VEGFR2 signalling

Author

Listed:
  • Rui Benedito

    (Max Planck Institute for Molecular Biomedicine, D-48149 Münster, Germany
    University of Münster, Faculty of Medicine, D-48149 Münster, Germany)

  • Susana F. Rocha

    (Max Planck Institute for Molecular Biomedicine, D-48149 Münster, Germany
    University of Münster, Faculty of Medicine, D-48149 Münster, Germany)

  • Marina Woeste

    (Max Planck Institute for Molecular Biomedicine, D-48149 Münster, Germany
    University of Münster, Faculty of Medicine, D-48149 Münster, Germany)

  • Martin Zamykal

    (Max Planck Institute for Molecular Biomedicine, D-48149 Münster, Germany
    University of Münster, Faculty of Medicine, D-48149 Münster, Germany)

  • Freddy Radtke

    (Ecole Polytechnique Fédérale de Lausanne (EPFL), Swiss Institute for Experimental Cancer Research (ISREC), CH-1015 Lausanne, Switzerland)

  • Oriol Casanovas

    (Translational Research Laboratory, Catalan Institute of Oncology, IDIBELL, 08907 L’Hospitalet de Llobregat, Spain)

  • Antonio Duarte

    (The Interdisciplinary Centre of Research in Animal Health (CIISA), Faculty of Veterinary Medicine, Technical University of Lisbon, 1300-474 Lisbon, Portugal)

  • Bronislaw Pytowski

    (ImClone Systems, 180 Varick Street)

  • Ralf H. Adams

    (Max Planck Institute for Molecular Biomedicine, D-48149 Münster, Germany
    University of Münster, Faculty of Medicine, D-48149 Münster, Germany)

Abstract

DLL4–Notch signalling suppresses endothelial sprouting and angiogenic growth through crosstalk with the vascular endothelial growth factor (VEGF) pathway; VEGF receptor 2 has been thought to have a crucial role in this crosstalk, but now VEGF receptor 3 is shown to be the more important modulator.

Suggested Citation

  • Rui Benedito & Susana F. Rocha & Marina Woeste & Martin Zamykal & Freddy Radtke & Oriol Casanovas & Antonio Duarte & Bronislaw Pytowski & Ralf H. Adams, 2012. "Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF–VEGFR2 signalling," Nature, Nature, vol. 484(7392), pages 110-114, April.
    • Handle: RePEc:nat:nature:v:484:y:2012:i:7392:d:10.1038_nature10908
    DOI: 10.1038/nature10908
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature10908
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature10908?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Fuchun Yang & Shiva Kalantari & Banzhan Ruan & Shaogang Sun & Zhaoqun Bian & Jun-Lin Guan, 2023. "Autophagy inhibition prevents lymphatic malformation progression to lymphangiosarcoma by decreasing osteopontin and Stat3 signaling," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Jeremiah Bernier-Latmani & Cristina Mauri & Rachel Marcone & François Renevey & Stephan Durot & Liqun He & Michael Vanlandewijck & Catherine Maclachlan & Suzel Davanture & Nicola Zamboni & Graham W. K, 2022. "ADAMTS18+ villus tip telocytes maintain a polarized VEGFA signaling domain and fenestrations in nutrient-absorbing intestinal blood vessels," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:484:y:2012:i:7392:d:10.1038_nature10908. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.