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Wild-type microglia arrest pathology in a mouse model of Rett syndrome

Author

Listed:
  • Noël C. Derecki

    (School of Medicine, University of Virginia
    Graduate Program in Neuroscience, School of Medicine, University of Virginia)

  • James C. Cronk

    (School of Medicine, University of Virginia
    Graduate Program in Neuroscience, School of Medicine, University of Virginia
    Medical Scientist Training Program, School of Medicine, University of Virginia)

  • Zhenjie Lu

    (School of Medicine, University of Virginia)

  • Eric Xu

    (School of Medicine, University of Virginia
    Undergraduate School of Arts and Sciences, University of Virginia)

  • Stephen B. G. Abbott

    (School of Medicine, University of Virginia)

  • Patrice G. Guyenet

    (School of Medicine, University of Virginia)

  • Jonathan Kipnis

    (School of Medicine, University of Virginia
    Graduate Program in Neuroscience, School of Medicine, University of Virginia
    Medical Scientist Training Program, School of Medicine, University of Virginia)

Abstract

Transplanting bone marrow from wild-type mice into MECP2-lacking mice results in wild-type microglial engraftment, extends lifespan and reduces symptoms of disease such as breathing and locomotor abnormalities, implicating microglia in the pathophysiology of Rett syndrome.

Suggested Citation

  • Noël C. Derecki & James C. Cronk & Zhenjie Lu & Eric Xu & Stephen B. G. Abbott & Patrice G. Guyenet & Jonathan Kipnis, 2012. "Wild-type microglia arrest pathology in a mouse model of Rett syndrome," Nature, Nature, vol. 484(7392), pages 105-109, April.
    • Handle: RePEc:nat:nature:v:484:y:2012:i:7392:d:10.1038_nature10907
    DOI: 10.1038/nature10907
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    Cited by:

    1. Takeo Kubota & Kazuki Mochizuki, 2016. "Epigenetic Effect of Environmental Factors on Autism Spectrum Disorders," IJERPH, MDPI, vol. 13(5), pages 1-12, May.

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