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Structure and mechanism of a glutamate–GABA antiporter

Author

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  • Dan Ma

    (Ministry of Education Protein Science Laboratory, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
    Tsinghua-Peking Joint Center for Life Sciences, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University)

  • Peilong Lu

    (Ministry of Education Protein Science Laboratory, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
    Tsinghua-Peking Joint Center for Life Sciences, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University)

  • Chuangye Yan

    (State Key Laboratory of Biomembrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
    Tsinghua-Peking Joint Center for Life Sciences, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University)

  • Chao Fan

    (Ministry of Education Protein Science Laboratory, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University)

  • Ping Yin

    (State Key Laboratory of Biomembrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University)

  • Jiawei Wang

    (State Key Laboratory of Biomembrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University)

  • Yigong Shi

    (Ministry of Education Protein Science Laboratory, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
    Tsinghua-Peking Joint Center for Life Sciences, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University)

Abstract

The X-ray crystal structure of the glutamate–GABA antiporter GadC is determined, revealing an inward-open conformation and providing insights into mechanism of amino acid antiport that is needed for acid resistance in bacteria.

Suggested Citation

  • Dan Ma & Peilong Lu & Chuangye Yan & Chao Fan & Ping Yin & Jiawei Wang & Yigong Shi, 2012. "Structure and mechanism of a glutamate–GABA antiporter," Nature, Nature, vol. 483(7391), pages 632-636, March.
    • Handle: RePEc:nat:nature:v:483:y:2012:i:7391:d:10.1038_nature10917
    DOI: 10.1038/nature10917
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    Cited by:

    1. Yaning Li & Yingying Guo & Angelika Bröer & Lu Dai & Stefan Brӧer & Renhong Yan, 2024. "Cryo-EM structure of the human Asc-1 transporter complex," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

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