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Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

Author

Listed:
  • Jan J. Molenaar

    (Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands)

  • Jan Koster

    (Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands)

  • Danny A. Zwijnenburg

    (Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands)

  • Peter van Sluis

    (Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands)

  • Linda J. Valentijn

    (Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands)

  • Ida van der Ploeg

    (Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands)

  • Mohamed Hamdi

    (Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands)

  • Johan van Nes

    (Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands)

  • Bart A. Westerman

    (Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands)

  • Jennemiek van Arkel

    (Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands)

  • Marli E. Ebus

    (Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands)

  • Franciska Haneveld

    (Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands)

  • Arjan Lakeman

    (Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands)

  • Linda Schild

    (Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands)

  • Piet Molenaar

    (Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands)

  • Peter Stroeken

    (Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands)

  • Max M. van Noesel

    (Erasmus MC-Sophia Children’s Hospital, 3015 GJ Rotterdam, The Netherlands)

  • Ingrid Øra

    (Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Skåne University Hospital, Lund University, 221 85 Lund, Sweden)

  • Evan E. Santo

    (Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands)

  • Huib N. Caron

    (Emma Children’s Hospital, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands)

  • Ellen M. Westerhout

    (Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands)

  • Rogier Versteeg

    (Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands)

Abstract

Whole-genome sequencing of neuroblastoma, a childhood tumour of the nervous system, shows that chromothripsis (a local shredding of chromosomes) and mutations in genes regulating neurite growth are associated with the most aggressive tumours.

Suggested Citation

  • Jan J. Molenaar & Jan Koster & Danny A. Zwijnenburg & Peter van Sluis & Linda J. Valentijn & Ida van der Ploeg & Mohamed Hamdi & Johan van Nes & Bart A. Westerman & Jennemiek van Arkel & Marli E. Ebus, 2012. "Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes," Nature, Nature, vol. 483(7391), pages 589-593, March.
    • Handle: RePEc:nat:nature:v:483:y:2012:i:7391:d:10.1038_nature10910
    DOI: 10.1038/nature10910
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    Citations

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    Cited by:

    1. Jenny Karlsson & Hiroaki Yasui & Adriana Mañas & Natalie Andersson & Karin Hansson & Kristina Aaltonen & Caroline Jansson & Geoffroy Durand & Naveen Ravi & Michele Ferro & Minjun Yang & Subhayan Chatt, 2024. "Early evolutionary branching across spatial domains predisposes to clonal replacement under chemotherapy in neuroblastoma," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Joanna Szydzik & Dan E. Lind & Badrul Arefin & Yeshwant Kurhe & Ganesh Umapathy & Joachim Tetteh Siaw & Arne Claeys & Jonatan L. Gabre & Jimmy Eynden & Bengt Hallberg & Ruth H. Palmer, 2021. "ATR inhibition enables complete tumour regression in ALK-driven NB mouse models," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    3. Bieke Decaesteker & Amber Louwagie & Siebe Loontiens & Fanny De Vloed & Sarah-Lee Bekaert & Juliette Roels & Suzanne Vanhauwaert & Sara De Brouwer & Ellen Sanders & Alla Berezovskaya & Geertrui Deneck, 2023. "SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    4. Ingrid M. Saldana-Guerrero & Luis F. Montano-Gutierrez & Katy Boswell & Christoph Hafemeister & Evon Poon & Lisa E. Shaw & Dylan Stavish & Rebecca A. Lea & Sara Wernig-Zorc & Eva Bozsaky & Irfete S. F, 2024. "A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations," Nature Communications, Nature, vol. 15(1), pages 1-25, December.
    5. Alexandra D’Oto & Jie Fang & Hongjian Jin & Beisi Xu & Shivendra Singh & Anoushka Mullasseril & Victoria Jones & Ahmed Abu-Zaid & Xinyu Buttlar & Bailey Cooke & Dongli Hu & Jason Shohet & Andrew J. Mu, 2021. "KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma," Nature Communications, Nature, vol. 12(1), pages 1-19, December.

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