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Tissue factor and PAR1 promote microbiota-induced intestinal vascular remodelling

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  • Christoph Reinhardt

    (Sahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, University of Gothenburg, 413 45 Gothenburg, Sweden
    University of Gothenburg, 413 45 Gothenburg, Sweden
    Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Experimental Research, 55131 Mainz, Germany)

  • Mattias Bergentall

    (Sahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, University of Gothenburg, 413 45 Gothenburg, Sweden
    University of Gothenburg, 413 45 Gothenburg, Sweden)

  • Thomas U. Greiner

    (Sahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, University of Gothenburg, 413 45 Gothenburg, Sweden
    University of Gothenburg, 413 45 Gothenburg, Sweden)

  • Florence Schaffner

    (The Scripps Research Institute)

  • Gunnel Östergren-Lundén

    (Sahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, University of Gothenburg, 413 45 Gothenburg, Sweden
    University of Gothenburg, 413 45 Gothenburg, Sweden)

  • Lars C. Petersen

    (Haemostasis Biology, Novo Nordisk A/S, DK-2760 Maalov, Denmark)

  • Wolfram Ruf

    (The Scripps Research Institute)

  • Fredrik Bäckhed

    (Sahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, University of Gothenburg, 413 45 Gothenburg, Sweden
    University of Gothenburg, 413 45 Gothenburg, Sweden
    Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen)

Abstract

Colonization of germ-free mice with microbiota promotes vascular growth in the small intestine through a mechanism involving tissue factor, PAR1 and Ang1.

Suggested Citation

  • Christoph Reinhardt & Mattias Bergentall & Thomas U. Greiner & Florence Schaffner & Gunnel Östergren-Lundén & Lars C. Petersen & Wolfram Ruf & Fredrik Bäckhed, 2012. "Tissue factor and PAR1 promote microbiota-induced intestinal vascular remodelling," Nature, Nature, vol. 483(7391), pages 627-631, March.
    • Handle: RePEc:nat:nature:v:483:y:2012:i:7391:d:10.1038_nature10893
    DOI: 10.1038/nature10893
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    Cited by:

    1. Karolina Skonieczna-Żydecka & Ewa Stachowska & Dominika Maciejewska & Karina Ryterska & Joanna Palma & Maja Czerwińska-Rogowska & Mariusz Kaczmarczyk & Anna Gudan & Honorata Mruk & Barbara Świniarska , 2018. "The Digestive Health among Participants of the Woodstock Rock Festival in Poland—A Cross-Sectional Survey," IJERPH, MDPI, vol. 15(10), pages 1-13, October.

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