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Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

Author

Listed:
  • Peppi Koivunen

    (Biocenter Oulu, Oulu Center for Cell-Matrix Research, University of Oulu, FIN-90014 Oulu, Finland)

  • Sungwoo Lee

    (Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Boston, Massachusetts 02215, USA)

  • Christopher G. Duncan

    (The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center)

  • Giselle Lopez

    (The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center)

  • Gang Lu

    (Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Boston, Massachusetts 02215, USA)

  • Shakti Ramkissoon

    (Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Boston, Massachusetts 02215, USA
    Brigham and Women’s Hospital
    Harvard Medical School)

  • Julie A. Losman

    (Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Boston, Massachusetts 02215, USA)

  • Päivi Joensuu

    (University of Oulu, FIN-90014 Oulu, Finland)

  • Ulrich Bergmann

    (Biocenter Oulu, Mass Spectrometry Core Facility, University of Oulu, FIN-90014 Oulu, Finland)

  • Stefan Gross

    (Agios Pharmaceuticals)

  • Jeremy Travins

    (Agios Pharmaceuticals)

  • Samuel Weiss

    (Hotchkiss Brain Institute, University of Calgary Faculty of Medicine, Calgary, Alberta T2N 4N1, Canada)

  • Ryan Looper

    (University of Utah)

  • Keith L. Ligon

    (Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Boston, Massachusetts 02215, USA
    Brigham and Women’s Hospital
    Harvard Medical School
    Children’s Hospital Boston)

  • Roel G. W. Verhaak

    (University of Texas MD Anderson Cancer Center)

  • Hai Yan

    (The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center)

  • William G. Kaelin Jr

    (Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Boston, Massachusetts 02215, USA
    Howard Hughes Medical Institute)

Abstract

The (R)-enantiomer of 2-hydroxyglutarate, which is produced when IDH is mutated in human tumours, is shown to stimulate the activity of the EGLN prolyl 4-hydroxylases, leading to diminished levels of HIF and enhanced human astrocyte proliferation.

Suggested Citation

  • Peppi Koivunen & Sungwoo Lee & Christopher G. Duncan & Giselle Lopez & Gang Lu & Shakti Ramkissoon & Julie A. Losman & Päivi Joensuu & Ulrich Bergmann & Stefan Gross & Jeremy Travins & Samuel Weiss & , 2012. "Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation," Nature, Nature, vol. 483(7390), pages 484-488, March.
    • Handle: RePEc:nat:nature:v:483:y:2012:i:7390:d:10.1038_nature10898
    DOI: 10.1038/nature10898
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    Cited by:

    1. Chen Zhu & Xin Chen & Tian-Qi Liu & Lin Cheng & Wen Cheng & Peng Cheng & An-Hua Wu, 2024. "Hexosaminidase B-driven cancer cell-macrophage co-dependency promotes glycolysis addiction and tumorigenesis in glioblastoma," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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