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IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

Author

Listed:
  • Sevin Turcan

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center)

  • Daniel Rohle

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
    Weill Cornell College of Medicine)

  • Anuj Goenka

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
    Memorial Sloan-Kettering Cancer Center)

  • Logan A. Walsh

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center)

  • Fang Fang

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center)

  • Emrullah Yilmaz

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center)

  • Carl Campos

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center)

  • Armida W. M. Fabius

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center)

  • Chao Lu

    (Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center
    University of Pennsylvania School of Medicine)

  • Patrick S. Ward

    (Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center
    University of Pennsylvania School of Medicine)

  • Craig B. Thompson

    (Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center)

  • Andrew Kaufman

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center)

  • Olga Guryanova

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center)

  • Ross Levine

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center)

  • Adriana Heguy

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center)

  • Agnes Viale

    (Genomics Core, Memorial Sloan-Kettering Cancer Center)

  • Luc G. T. Morris

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
    Memorial Sloan-Kettering Cancer Center)

  • Jason T. Huse

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
    Memorial Sloan-Kettering Cancer Center)

  • Ingo K. Mellinghoff

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
    Weill Cornell College of Medicine
    Memorial Sloan-Kettering Cancer Center
    Brain Tumor Center, Memorial Sloan-Kettering Cancer Center)

  • Timothy A. Chan

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
    Weill Cornell College of Medicine
    Memorial Sloan-Kettering Cancer Center
    Brain Tumor Center, Memorial Sloan-Kettering Cancer Center)

Abstract

Mutation of isocitrate dehydrogenase 1 (IDH1) is shown to induce DNA hypermethylation and to remodel the epigenome to resemble that of gliomas with the CpG island methylator phenotype.

Suggested Citation

  • Sevin Turcan & Daniel Rohle & Anuj Goenka & Logan A. Walsh & Fang Fang & Emrullah Yilmaz & Carl Campos & Armida W. M. Fabius & Chao Lu & Patrick S. Ward & Craig B. Thompson & Andrew Kaufman & Olga Gur, 2012. "IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype," Nature, Nature, vol. 483(7390), pages 479-483, March.
    • Handle: RePEc:nat:nature:v:483:y:2012:i:7390:d:10.1038_nature10866
    DOI: 10.1038/nature10866
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    Cited by:

    1. Walid K. Chatila & Henry Walch & Jaclyn F. Hechtman & Sydney M. Moyer & Valeria Sgambati & David M. Faleck & Amitabh Srivastava & Laura Tang & Jamal Benhamida & Dorina Ismailgeci & Carl Campos & Fan W, 2023. "Integrated clinical and genomic analysis identifies driver events and molecular evolution of colitis-associated cancers," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Mehmet Baysan & Serdar Bozdag & Margaret C Cam & Svetlana Kotliarova & Susie Ahn & Jennifer Walling & Jonathan K Killian & Holly Stevenson & Paul Meltzer & Howard A Fine, 2012. "G-Cimp Status Prediction Of Glioblastoma Samples Using mRNA Expression Data," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-10, November.
    3. Siobhan Conroy & Frank A E Kruyt & Justin V Joseph & Veerakumar Balasubramaniyan & Krishna P Bhat & Michiel Wagemakers & Roelien H Enting & Annemiek M E Walenkamp & Wilfred F A den Dunnen, 2014. "Subclassification of Newly Diagnosed Glioblastomas through an Immunohistochemical Approach," PLOS ONE, Public Library of Science, vol. 9(12), pages 1-21, December.
    4. Anna M Dahlin & Carl Wibom & Soma Ghasimi & Thomas Brännström & Ulrika Andersson & Beatrice Melin, 2016. "Relation between Established Glioma Risk Variants and DNA Methylation in the Tumor," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-14, October.

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