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IDH mutation impairs histone demethylation and results in a block to cell differentiation

Author

Listed:
  • Chao Lu

    (Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center
    Perelman School of Medicine, University of Pennsylvania)

  • Patrick S. Ward

    (Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center
    Perelman School of Medicine, University of Pennsylvania)

  • Gurpreet S. Kapoor

    (Perelman School of Medicine, University of Pennsylvania)

  • Dan Rohle

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
    Weill Cornell Medical College)

  • Sevin Turcan

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center)

  • Omar Abdel-Wahab

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
    Leukemia Service, Memorial Sloan-Kettering Cancer Center)

  • Christopher R. Edwards

    (Perelman School of Medicine, University of Pennsylvania)

  • Raya Khanin

    (Bioinformatics Core, Memorial Sloan-Kettering Cancer Center)

  • Maria E. Figueroa

    (Weill Cornell Medical College)

  • Ari Melnick

    (Weill Cornell Medical College)

  • Kathryn E. Wellen

    (Perelman School of Medicine, University of Pennsylvania)

  • Donald M. O’Rourke

    (Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • Shelley L. Berger

    (Perelman School of Medicine, University of Pennsylvania)

  • Timothy A. Chan

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center)

  • Ross L. Levine

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
    Leukemia Service, Memorial Sloan-Kettering Cancer Center)

  • Ingo K. Mellinghoff

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
    Weill Cornell Medical College
    Memorial Sloan-Kettering Cancer Center)

  • Craig B. Thompson

    (Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center)

Abstract

Cancer-associated IDH mutants that produce 2-hydroxyglutarate are shown to prevent the histone demethylation that is required for lineage-specific progenitor cells to differentiate into terminally differentiated cells.

Suggested Citation

  • Chao Lu & Patrick S. Ward & Gurpreet S. Kapoor & Dan Rohle & Sevin Turcan & Omar Abdel-Wahab & Christopher R. Edwards & Raya Khanin & Maria E. Figueroa & Ari Melnick & Kathryn E. Wellen & Donald M. O’, 2012. "IDH mutation impairs histone demethylation and results in a block to cell differentiation," Nature, Nature, vol. 483(7390), pages 474-478, March.
    • Handle: RePEc:nat:nature:v:483:y:2012:i:7390:d:10.1038_nature10860
    DOI: 10.1038/nature10860
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    Cited by:

    1. Walid K. Chatila & Henry Walch & Jaclyn F. Hechtman & Sydney M. Moyer & Valeria Sgambati & David M. Faleck & Amitabh Srivastava & Laura Tang & Jamal Benhamida & Dorina Ismailgeci & Carl Campos & Fan W, 2023. "Integrated clinical and genomic analysis identifies driver events and molecular evolution of colitis-associated cancers," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Sumin Feng & Sai Ma & Kejiao Li & Shengxian Gao & Shaokai Ning & Jinfeng Shang & Ruiyuan Guo & Yingying Chen & Britny Blumenfeld & Itamar Simon & Qing Li & Rong Guo & Dongyi Xu, 2022. "RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Kotaro Soeda & Takayoshi Sasako & Kenichiro Enooku & Naoto Kubota & Naoki Kobayashi & Yoshiko Matsumoto Ikushima & Motoharu Awazawa & Ryotaro Bouchi & Gotaro Toda & Tomoharu Yamada & Takuma Nakatsuka , 2023. "Gut insulin action protects from hepatocarcinogenesis in diabetic mice comorbid with nonalcoholic steatohepatitis," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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