IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v483y2012i7389d10.1038_nature10879.html
   My bibliography  Save this article

Phase transitions in the assembly of multivalent signalling proteins

Author

Listed:
  • Pilong Li

    (University of Texas Southwestern Medical Center)

  • Sudeep Banjade

    (University of Texas Southwestern Medical Center)

  • Hui-Chun Cheng

    (University of Texas Southwestern Medical Center)

  • Soyeon Kim

    (University of Texas Southwestern Medical Center)

  • Baoyu Chen

    (University of Texas Southwestern Medical Center)

  • Liang Guo

    (BioCAT of IIT at the Advanced Photon Source, Argonne National Laboratory, 9700 South Cass Avenue)

  • Marc Llaguno

    (University of Texas Southwestern Medical Center)

  • Javoris V. Hollingsworth

    (Louisiana State University)

  • David S. King

    (University of California)

  • Salman F. Banani

    (University of Texas Southwestern Medical Center)

  • Paul S. Russo

    (Louisiana State University)

  • Qiu-Xing Jiang

    (University of Texas Southwestern Medical Center)

  • B. Tracy Nixon

    (The Pennsylvania State University, University Park)

  • Michael K. Rosen

    (University of Texas Southwestern Medical Center)

Abstract

The mechanisms by which the ångström-scale molecular properties of cells are translated to micrometre-scale macroscopic properties have not been well understood, but this study shows that when multivalent proteins interact with each other, they undergo a switch-like phase separation, which is concomitant with a transition from small complexes to huge polymeric assemblies, as the concentration increases.

Suggested Citation

  • Pilong Li & Sudeep Banjade & Hui-Chun Cheng & Soyeon Kim & Baoyu Chen & Liang Guo & Marc Llaguno & Javoris V. Hollingsworth & David S. King & Salman F. Banani & Paul S. Russo & Qiu-Xing Jiang & B. Tra, 2012. "Phase transitions in the assembly of multivalent signalling proteins," Nature, Nature, vol. 483(7389), pages 336-340, March.
    • Handle: RePEc:nat:nature:v:483:y:2012:i:7389:d:10.1038_nature10879
    DOI: 10.1038/nature10879
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature10879
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature10879?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:483:y:2012:i:7389:d:10.1038_nature10879. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.