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Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis

Author

Listed:
  • Kinya Hotta

    (National University of Singapore, 14 Science Drive 4, 117543 Singapore)

  • Xi Chen

    (National University of Singapore, 14 Science Drive 4, 117543 Singapore)

  • Robert S. Paton

    (Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK)

  • Atsushi Minami

    (Hokkaido University, Graduate School of Science, North 10 West 8, Sapporo 060-0810, Japan)

  • Hao Li

    (National University of Singapore, 14 Science Drive 4, 117543 Singapore)

  • Kunchithapadam Swaminathan

    (National University of Singapore, 14 Science Drive 4, 117543 Singapore)

  • Irimpan I. Mathews

    (Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, 2575 Sand Hill Road MS 99, Menlo Park, California 95124, USA)

  • Kenji Watanabe

    (University of Shizuoka, Graduate School of Pharmaceutical Sciences, 52-1 Yada, Suruga-ku, Shizuoka City, Shizuoka 422-8526, Japan)

  • Hideaki Oikawa

    (Hokkaido University, Graduate School of Science, North 10 West 8, Sapporo 060-0810, Japan)

  • Kendall N. Houk

    (University of California Los Angeles, 607 Charles E. Young Drive East, Box 951569, Los Angeles, California 90095-1569, USA)

  • Chu-Young Kim

    (National University of Singapore, 14 Science Drive 4, 117543 Singapore)

Abstract

The X-ray crystal structure of the epoxide hydrolase Lsd19 in complex with its substrate and product analogue is determined, providing insight into a general mechanism of enzyme-catalysed formation of polyether natural products.

Suggested Citation

  • Kinya Hotta & Xi Chen & Robert S. Paton & Atsushi Minami & Hao Li & Kunchithapadam Swaminathan & Irimpan I. Mathews & Kenji Watanabe & Hideaki Oikawa & Kendall N. Houk & Chu-Young Kim, 2012. "Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis," Nature, Nature, vol. 483(7389), pages 355-358, March.
    • Handle: RePEc:nat:nature:v:483:y:2012:i:7389:d:10.1038_nature10865
    DOI: 10.1038/nature10865
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    Cited by:

    1. Jun-Kuan Li & Ge Qu & Xu Li & Yuchen Tian & Chengsen Cui & Fa-Guang Zhang & Wuyuan Zhang & Jun-An Ma & Manfred T. Reetz & Zhoutong Sun, 2022. "Rational enzyme design for enabling biocatalytic Baldwin cyclization and asymmetric synthesis of chiral heterocycles," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Qian Wang & Ning Liu & Yaming Deng & Yuze Guan & Hongli Xiao & Tara A. Nitka & Hui Yang & Anju Yadav & Lela Vukovic & Irimpan I. Mathews & Xi Chen & Chu-Young Kim, 2023. "Triepoxide formation by a flavin-dependent monooxygenase in monensin biosynthesis," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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