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Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

Author

Listed:
  • Atsuhiko Ichimura

    (Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan)

  • Akira Hirasawa

    (Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan)

  • Odile Poulain-Godefroy

    (Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59000, France
    Lille Nord de France University, Lille 59000, France)

  • Amélie Bonnefond

    (Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59000, France
    Lille Nord de France University, Lille 59000, France)

  • Takafumi Hara

    (Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan)

  • Loïc Yengo

    (Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59000, France
    Lille Nord de France University, Lille 59000, France)

  • Ikuo Kimura

    (Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan)

  • Audrey Leloire

    (Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59000, France
    Lille Nord de France University, Lille 59000, France)

  • Ning Liu

    (Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan)

  • Keiko Iida

    (Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan)

  • Hélène Choquet

    (Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59000, France
    Lille Nord de France University, Lille 59000, France)

  • Philippe Besnard

    (Institut National de la Santé et de la Recherche Médicale (Inserm)-UMR U866, Physiologie de la Nutrition, Bourgogne University, AgroSup Dijon, Dijon 21078, France)

  • Cécile Lecoeur

    (Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59000, France
    Lille Nord de France University, Lille 59000, France)

  • Sidonie Vivequin

    (Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59000, France
    Lille Nord de France University, Lille 59000, France)

  • Kumiko Ayukawa

    (Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan)

  • Masato Takeuchi

    (Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan)

  • Kentaro Ozawa

    (Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan)

  • Maithé Tauber

    (Inserm-U563, Children’s Hospital, Centre Hospitalier Universitaire, Toulouse 31000, France)

  • Claudio Maffeis

    (Regional Centre for Juvenile Diabetes, Obesity and Clinical Nutrition, Verona 37134, Italy
    Biology-Genetics, Section of Paediatrics, University of Verona, Verona 37134, Italy)

  • Anita Morandi

    (Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59000, France
    Lille Nord de France University, Lille 59000, France
    Regional Centre for Juvenile Diabetes, Obesity and Clinical Nutrition, Verona 37134, Italy)

  • Raffaella Buzzetti

    (La Sapienza University, Rome 00161, Italy)

  • Paul Elliott

    (Medical Research Council-HPA Centre for Environment and Health, School of Public Health, St Mary’s campus, Imperial College London, London W2 1PG, UK)

  • Anneli Pouta

    (National Public Health Institute, Biocenter Oulu, University of Oulu, Oulu 90220, Finland
    Institute of Clinical Medicine/Obstetrics and Gynecology, University of Oulu, Oulu 90220, Finland)

  • Marjo-Riitta Jarvelin

    (Medical Research Council-HPA Centre for Environment and Health, School of Public Health, St Mary’s campus, Imperial College London, London W2 1PG, UK
    National Public Health Institute, Biocenter Oulu, University of Oulu, Oulu 90220, Finland
    Institute of Health Sciences, University of Oulu, Oulu 90220, Finland)

  • Antje Körner

    (Center for Pediatric Research, University of Leipzig, Leipzig 04317, Germany)

  • Wieland Kiess

    (Center for Pediatric Research, University of Leipzig, Leipzig 04317, Germany)

  • Marie Pigeyre

    (Inserm-U859, Lille Nord de France University, Lille 59000, France
    Lille University Hospital, Nutrition, Lille 59000, France)

  • Roberto Caiazzo

    (Inserm-U859, Lille Nord de France University, Lille 59000, France
    Lille University Hospital, Endocrine Surgery, Lille 59000, France)

  • Wim Van Hul

    (University of Antwerp, Antwerp 2610, Belgium)

  • Luc Van Gaal

    (Antwerp University Hospital, Antwerp 2650, Belgium)

  • Fritz Horber

    (Clinic Lindberg, Winterthur 8400, and University of Berne, Berne 3011, Switzerland)

  • Beverley Balkau

    (Inserm-U780, Centre for research in Epidemiology and Population Health (CRESP), Villejuif 94800, France
    Paris-Sud 11 University, Orsay 91405, France)

  • Claire Lévy-Marchal

    (Inserm-U690, Robert Debré hospital, Paris 75935, France)

  • Konstantinos Rouskas

    (Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59000, France
    Lille Nord de France University, Lille 59000, France
    Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki 541 24, Greece)

  • Anastasia Kouvatsi

    (Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki 541 24, Greece)

  • Johannes Hebebrand

    (University of Duisburg-Essen, Essen 45147, Germany)

  • Anke Hinney

    (University of Duisburg-Essen, Essen 45147, Germany)

  • Andre Scherag

    (Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen 45122, Germany)

  • François Pattou

    (Inserm-U859, Lille Nord de France University, Lille 59000, France
    Lille University Hospital, Endocrine Surgery, Lille 59000, France)

  • David Meyre

    (Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59000, France
    Lille Nord de France University, Lille 59000, France
    McMaster University, Hamilton, Ontario L8S 4L8, Canada)

  • Taka-aki Koshimizu

    (Jichi Medical University, Tochigi 329-0498, Japan)

  • Isabelle Wolowczuk

    (Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59000, France
    Lille Nord de France University, Lille 59000, France)

  • Gozoh Tsujimoto

    (Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan)

  • Philippe Froguel

    (Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille 59000, France
    Lille Nord de France University, Lille 59000, France
    School of Public Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK)

Abstract

Mice deficient in the lipid sensor GPR120 develop obesity, glucose intolerance and fatty liver when fed a high-fat diet, and a loss-of-function variant in the GPR120 gene strongly contributes to increased obesity in human.

Suggested Citation

  • Atsuhiko Ichimura & Akira Hirasawa & Odile Poulain-Godefroy & Amélie Bonnefond & Takafumi Hara & Loïc Yengo & Ikuo Kimura & Audrey Leloire & Ning Liu & Keiko Iida & Hélène Choquet & Philippe Besnard &, 2012. "Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human," Nature, Nature, vol. 483(7389), pages 350-354, March.
    • Handle: RePEc:nat:nature:v:483:y:2012:i:7389:d:10.1038_nature10798
    DOI: 10.1038/nature10798
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    Cited by:

    1. Dongliang Lu & Anyuan He & Min Tan & Marguerite Mrad & Amal El Daibani & Donghua Hu & Xuejing Liu & Brian Kleiboeker & Tao Che & Fong-Fu Hsu & Monika Bambouskova & Clay F. Semenkovich & Irfan J. Lodhi, 2024. "Liver ACOX1 regulates levels of circulating lipids that promote metabolic health through adipose remodeling," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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