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Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity

Author

Listed:
  • Xiaodong Jiang

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Rachael A. Clark

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Luzheng Liu

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Amy J. Wagers

    (Harvard University, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Joslin Diabetes Center)

  • Robert C. Fuhlbrigge

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Thomas S. Kupper

    (Brigham and Women’s Hospital, Harvard Medical School)

Abstract

Local skin infection is shown to generate long-lived T cells that reside throughout the skin and are potent effector cells, superior to circulating memory T cells in providing rapid long-term protection again cutaneous re-infection.

Suggested Citation

  • Xiaodong Jiang & Rachael A. Clark & Luzheng Liu & Amy J. Wagers & Robert C. Fuhlbrigge & Thomas S. Kupper, 2012. "Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity," Nature, Nature, vol. 483(7388), pages 227-231, March.
    • Handle: RePEc:nat:nature:v:483:y:2012:i:7388:d:10.1038_nature10851
    DOI: 10.1038/nature10851
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    Cited by:

    1. Hongbin Wang & Carol Hoffman & Xinghong Yang & Beata Clapp & David W Pascual, 2020. "Targeting resident memory T cell immunity culminates in pulmonary and systemic protection against Brucella infection," PLOS Pathogens, Public Library of Science, vol. 16(1), pages 1-31, January.
    2. Vitaly V Ganusov & Jeremy Auerbach, 2014. "Mathematical Modeling Reveals Kinetics of Lymphocyte Recirculation in the Whole Organism," PLOS Computational Biology, Public Library of Science, vol. 10(5), pages 1-15, May.
    3. Kerry J. Laing & Werner J. D. Ouwendijk & Victoria L. Campbell & Christopher L. McClurkan & Shahin Mortazavi & Michael Elder Waters & Maxwell P. Krist & Richard Tu & Nhi Nguyen & Krithi Basu & Congron, 2022. "Selective retention of virus-specific tissue-resident T cells in healed skin after recovery from herpes zoster," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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