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An epigenetic blockade of cognitive functions in the neurodegenerating brain

Author

Listed:
  • Johannes Gräff

    (Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    Howard Hughes Medical Institute, Massachusetts Institute of Technology
    Stanley Center for Psychiatric Research, Broad Institute of Harvard University and Massachusetts Institute of Technology)

  • Damien Rei

    (Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    Howard Hughes Medical Institute, Massachusetts Institute of Technology)

  • Ji-Song Guan

    (Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    Howard Hughes Medical Institute, Massachusetts Institute of Technology
    Stanley Center for Psychiatric Research, Broad Institute of Harvard University and Massachusetts Institute of Technology)

  • Wen-Yuan Wang

    (Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    Howard Hughes Medical Institute, Massachusetts Institute of Technology
    Stanley Center for Psychiatric Research, Broad Institute of Harvard University and Massachusetts Institute of Technology)

  • Jinsoo Seo

    (Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    Howard Hughes Medical Institute, Massachusetts Institute of Technology)

  • Krista M. Hennig

    (Stanley Center for Psychiatric Research, Broad Institute of Harvard University and Massachusetts Institute of Technology
    Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School)

  • Thomas J. F. Nieland

    (Stanley Center for Psychiatric Research, Broad Institute of Harvard University and Massachusetts Institute of Technology)

  • Daniel M. Fass

    (Stanley Center for Psychiatric Research, Broad Institute of Harvard University and Massachusetts Institute of Technology
    Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School)

  • Patricia F. Kao

    (Boston University School of Medicine)

  • Martin Kahn

    (Picower Institute for Learning and Memory, Massachusetts Institute of Technology)

  • Susan C. Su

    (Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    Howard Hughes Medical Institute, Massachusetts Institute of Technology)

  • Alireza Samiei

    (Picower Institute for Learning and Memory, Massachusetts Institute of Technology)

  • Nadine Joseph

    (Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    Howard Hughes Medical Institute, Massachusetts Institute of Technology
    Stanley Center for Psychiatric Research, Broad Institute of Harvard University and Massachusetts Institute of Technology)

  • Stephen J. Haggarty

    (Stanley Center for Psychiatric Research, Broad Institute of Harvard University and Massachusetts Institute of Technology
    Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School)

  • Ivana Delalle

    (Boston University School of Medicine)

  • Li-Huei Tsai

    (Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    Howard Hughes Medical Institute, Massachusetts Institute of Technology
    Stanley Center for Psychiatric Research, Broad Institute of Harvard University and Massachusetts Institute of Technology)

Abstract

Histone deacetylase 2 is shown to suppress genes involved in cognitive function epigenetically, potentially opening the door to treatments for Alzheimer’s and other neurodegenerative diseases by developing HDAC2-selective inhibitors.

Suggested Citation

  • Johannes Gräff & Damien Rei & Ji-Song Guan & Wen-Yuan Wang & Jinsoo Seo & Krista M. Hennig & Thomas J. F. Nieland & Daniel M. Fass & Patricia F. Kao & Martin Kahn & Susan C. Su & Alireza Samiei & Nadi, 2012. "An epigenetic blockade of cognitive functions in the neurodegenerating brain," Nature, Nature, vol. 483(7388), pages 222-226, March.
    • Handle: RePEc:nat:nature:v:483:y:2012:i:7388:d:10.1038_nature10849
    DOI: 10.1038/nature10849
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    Cited by:

    1. Tharick A. Pascoal & Mira Chamoun & Elad Lax & Hsiao-Ying Wey & Monica Shin & Kok Pin Ng & Min Su Kang & Sulantha Mathotaarachchi & Andrea L. Benedet & Joseph Therriault & Firoza Z. Lussier & Frederic, 2022. "[11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Tian Wang & Jie Zhang & Yi Xu, 2020. "Epigenetic Basis of Lead-Induced Neurological Disorders," IJERPH, MDPI, vol. 17(13), pages 1-23, July.
    3. Masataka Kikuchi & Soichi Ogishima & Tadashi Miyamoto & Akinori Miyashita & Ryozo Kuwano & Jun Nakaya & Hiroshi Tanaka, 2013. "Identification of Unstable Network Modules Reveals Disease Modules Associated with the Progression of Alzheimer’s Disease," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-1, November.

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