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The sirtuin SIRT6 regulates lifespan in male mice

Author

Listed:
  • Yariv Kanfi

    (The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University)

  • Shoshana Naiman

    (The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University)

  • Gail Amir

    (Hadassah Medical Center and Hebrew University)

  • Victoria Peshti

    (The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University)

  • Guy Zinman

    (Lane Center for Computational Biology, School of Computer Science, Carnegie Mellon University)

  • Liat Nahum

    (The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University)

  • Ziv Bar-Joseph

    (Lane Center for Computational Biology, School of Computer Science, Carnegie Mellon University)

  • Haim Y. Cohen

    (The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University)

Abstract

The role of sirtuins in longevity is controversial, and little is known about mammalian sirtuins; now, male mice that overexpress SIRT6 are shown to have a longer lifespan than wild-type mice, unlike their female counterparts.

Suggested Citation

  • Yariv Kanfi & Shoshana Naiman & Gail Amir & Victoria Peshti & Guy Zinman & Liat Nahum & Ziv Bar-Joseph & Haim Y. Cohen, 2012. "The sirtuin SIRT6 regulates lifespan in male mice," Nature, Nature, vol. 483(7388), pages 218-221, March.
    • Handle: RePEc:nat:nature:v:483:y:2012:i:7388:d:10.1038_nature10815
    DOI: 10.1038/nature10815
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