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Strict evolutionary conservation followed rapid gene loss on human and rhesus Y chromosomes

Author

Listed:
  • Jennifer F. Hughes

    (Howard Hughes Medical Institute, Massachusetts Institute of Technology, 9 Cambridge Center)

  • Helen Skaletsky

    (Howard Hughes Medical Institute, Massachusetts Institute of Technology, 9 Cambridge Center)

  • Laura G. Brown

    (Howard Hughes Medical Institute, Massachusetts Institute of Technology, 9 Cambridge Center)

  • Tatyana Pyntikova

    (Howard Hughes Medical Institute, Massachusetts Institute of Technology, 9 Cambridge Center)

  • Tina Graves

    (The Genome Institute, Washington University School of Medicine, 4444 Forest Park Boulevard, St. Louis, Missouri 63108, USA)

  • Robert S. Fulton

    (The Genome Institute, Washington University School of Medicine, 4444 Forest Park Boulevard, St. Louis, Missouri 63108, USA)

  • Shannon Dugan

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Yan Ding

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Christian J. Buhay

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Colin Kremitzki

    (The Genome Institute, Washington University School of Medicine, 4444 Forest Park Boulevard, St. Louis, Missouri 63108, USA)

  • Qiaoyan Wang

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Hua Shen

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Michael Holder

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Donna Villasana

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Lynne V. Nazareth

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Andrew Cree

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Laura Courtney

    (The Genome Institute, Washington University School of Medicine, 4444 Forest Park Boulevard, St. Louis, Missouri 63108, USA)

  • Joelle Veizer

    (The Genome Institute, Washington University School of Medicine, 4444 Forest Park Boulevard, St. Louis, Missouri 63108, USA)

  • Holland Kotkiewicz

    (The Genome Institute, Washington University School of Medicine, 4444 Forest Park Boulevard, St. Louis, Missouri 63108, USA)

  • Ting-Jan Cho

    (Howard Hughes Medical Institute, Massachusetts Institute of Technology, 9 Cambridge Center)

  • Natalia Koutseva

    (Howard Hughes Medical Institute, Massachusetts Institute of Technology, 9 Cambridge Center)

  • Steve Rozen

    (Howard Hughes Medical Institute, Massachusetts Institute of Technology, 9 Cambridge Center)

  • Donna M. Muzny

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Wesley C. Warren

    (The Genome Institute, Washington University School of Medicine, 4444 Forest Park Boulevard, St. Louis, Missouri 63108, USA)

  • Richard A. Gibbs

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Richard K. Wilson

    (The Genome Institute, Washington University School of Medicine, 4444 Forest Park Boulevard, St. Louis, Missouri 63108, USA)

  • David C. Page

    (Howard Hughes Medical Institute, Massachusetts Institute of Technology, 9 Cambridge Center)

Abstract

The male-specific region of rhesus macaque and human Y chromosome (MSY) are sequenced and compared to the human MSY, showing that during the last 25 million years MSY gene loss in the rhesus and human lineages was limited to the youngest stratum (stratum 5), whereas gene loss in the older strata ceased more than 25 million years ago.

Suggested Citation

  • Jennifer F. Hughes & Helen Skaletsky & Laura G. Brown & Tatyana Pyntikova & Tina Graves & Robert S. Fulton & Shannon Dugan & Yan Ding & Christian J. Buhay & Colin Kremitzki & Qiaoyan Wang & Hua Shen &, 2012. "Strict evolutionary conservation followed rapid gene loss on human and rhesus Y chromosomes," Nature, Nature, vol. 483(7387), pages 82-86, March.
    • Handle: RePEc:nat:nature:v:483:y:2012:i:7387:d:10.1038_nature10843
    DOI: 10.1038/nature10843
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    Cited by:

    1. Temitayo A. Olagunju & Benjamin D. Rosen & Holly L. Neibergs & Gabrielle M. Becker & Kimberly M. Davenport & Christine G. Elsik & Tracy S. Hadfield & Sergey Koren & Kristen L. Kuhn & Arang Rhie & Kati, 2024. "Telomere-to-telomere assemblies of cattle and sheep Y-chromosomes uncover divergent structure and gene content," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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