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Structural and functional conservation of key domains in InsP3 and ryanodine receptors

Author

Listed:
  • Min-Duk Seo

    (University of Toronto, Ontario M5G 1L7, Canada
    Present address: College of Pharmacy, Ajou University, Suwon 443-749, Korea.)

  • Saroj Velamakanni

    (University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK)

  • Noboru Ishiyama

    (University of Toronto, Ontario M5G 1L7, Canada)

  • Peter B. Stathopulos

    (University of Toronto, Ontario M5G 1L7, Canada)

  • Ana M. Rossi

    (University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK)

  • Samir A. Khan

    (University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK)

  • Philippa Dale

    (University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK)

  • Congmin Li

    (University of California)

  • James B. Ames

    (University of California)

  • Mitsuhiko Ikura

    (University of Toronto, Ontario M5G 1L7, Canada)

  • Colin W. Taylor

    (University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK)

Abstract

Structures of the amino-terminal region of inositol-1,4,5-trisphosphate receptor 1 with and without InsP3 bound reveal two discrete interfaces between the InsP3-binding core and suppressor domain that are similar to and functionally interchangeable with those in the equivalent domains of ryanodine receptor 1.

Suggested Citation

  • Min-Duk Seo & Saroj Velamakanni & Noboru Ishiyama & Peter B. Stathopulos & Ana M. Rossi & Samir A. Khan & Philippa Dale & Congmin Li & James B. Ames & Mitsuhiko Ikura & Colin W. Taylor, 2012. "Structural and functional conservation of key domains in InsP3 and ryanodine receptors," Nature, Nature, vol. 483(7387), pages 108-112, March.
    • Handle: RePEc:nat:nature:v:483:y:2012:i:7387:d:10.1038_nature10751
    DOI: 10.1038/nature10751
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    Cited by:

    1. Navid Paknejad & Vinay Sapuru & Richard K. Hite, 2023. "Structural titration reveals Ca2+-dependent conformational landscape of the IP3 receptor," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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